Kaur Gurpreet, Mehta S K
Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, India.
Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, India.
Int J Pharm. 2017 Aug 30;529(1-2):134-160. doi: 10.1016/j.ijpharm.2017.06.059. Epub 2017 Jun 19.
The present review deals with the progress of Polysorbates (Tween) based microemulsions in drug delivery. PEGylated Sorbitan Fatty Acid Esters (Tweens/Polysorbates) are one of the most used non-ionic surfactants. Particularly, Polysorbates based microemulsion has been widely used for enhancing solubilization of poorly soluble drugs. This article deals with underlying the preclinical factors which affect the solubilization efficacy of Tween formulations, implication of pharmaceutically accepted vectors in terms of absorption, bioavailability, biological fate and potential toxicity. Antimicrobial activity of Tween microemulsion formulations has also been addressed emphasising the role of Tween. The review contains comprehensive knowledge/literature related to physicochemical parameters and biological fate of different Polysorbates and takes into account all the parameters and observations that make Tween a very convenient and safe choice for the use as pharmaceutical excipient for microemulsion formulations.
本综述探讨了基于聚山梨酯（吐温）的微乳剂在药物递送方面的进展。聚乙二醇化脱水山梨醇脂肪酸酯（吐温/聚山梨酯）是最常用的非离子表面活性剂之一。特别是，基于聚山梨酯的微乳剂已被广泛用于提高难溶性药物的溶解度。本文探讨了影响吐温制剂增溶效果的临床前因素，以及在吸收、生物利用度、生物命运和潜在毒性方面药学上认可的载体的意义。还讨论了吐温微乳剂制剂的抗菌活性，强调了吐温的作用。该综述包含了与不同聚山梨酯的物理化学参数和生物命运相关的全面知识/文献，并考虑了所有使吐温成为微乳剂制剂药用辅料非常方便和安全选择的参数和观察结果。
