Silva Ricardo Teixeira E, Fernandes Renan Jose Rodrigues, Ono Allan Hiroshi DE Araújo, Marcon Raphael Martus, Cristante Alexandre Fogaça, Barros Tarcisio Eloy Pessoa DE
. Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto de Ortopedia e Traumatologia, São Paulo, SP, Brazil.
. Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
Acta Ortop Bras. 2017 Jan-Feb;25(1):15-17. doi: 10.1590/1413-785220172501168600.
To evaluate the hormonal profile of patients with adolescent idiopathic scoliosis (AIS) and its relationship to the severity of the curvature and quality of life
Patients with scoliosis (Cobb angle above 10°), of both genders, diagnosed after 10 years of age were included, excluding those who presented other condition that could lead to scoliosis. Serum levels of 25-hydroxyvitamin D (25-OHD), cortisol and gastrin were correlated with Cobb angle and quality of life, measured by the SRS-30 questionnaire
The levels of 25-OHD decreased in 97% of patients. There was an inverse relationship between gastrin levels and quality of life (p = 0.016). Moreover, there was an inverse correlation between the value of Cobb angle and quality of life (p = 0.036). There were no changes in cortisol levels. There was no correlation between Cobb angle and any of the hormones measured
The patients had levels of 25-OHD diminished, strengthening the hypothesis of its involvement in the development of AIS. This study also suggests that increased gastrin levels may be associated with a worse quality of life in patients with AIS.
评估青少年特发性脊柱侧凸（AIS）患者的激素水平及其与脊柱侧凸严重程度和生活质量的关系。
纳入10岁以后诊断出的脊柱侧凸患者（Cobb角大于10°），男女不限，排除那些患有其他可能导致脊柱侧凸疾病的患者。通过SRS - 30问卷测量血清25 - 羟维生素D（25 - OHD）、皮质醇和胃泌素水平，并将其与Cobb角和生活质量进行相关性分析。
97%的患者25 - OHD水平下降。胃泌素水平与生活质量呈负相关（p = 0.016）。此外，Cobb角值与生活质量呈负相关（p = 0.036）。皮质醇水平无变化。Cobb角与所测任何一种激素之间均无相关性。
患者的25 - OHD水平降低，强化了其参与AIS发病机制的假说。本研究还表明，胃泌素水平升高可能与AIS患者较差的生活质量相关。
