Sales de Gauzy Jérôme, Gennero Isabelle, Delrous Olivier, Salles Jean-Pierre, Lepage Benoit, Accadbled Franck
Pediatric Orthopaedics Unit, Children Hospital, CHU de Toulouse, France ; Biomechanics Laboratory, Paul-Sabatier University, Toulouse, France.
INSERM Unit 1043, Physiopathology Center of Toulouse Purpan (CTPT), Paul-Sabatier University, Toulouse, France ; Biochemistry Laboratory, Institut Fédératif de Biologie, University Hospital Center, CHU de Toulouse, France.
Scoliosis. 2015 Nov 30;10:33. doi: 10.1186/s13013-015-0054-7. eCollection 2015.
A control study was designed to investigate circulating Ghrelin levels in adolescent girls with adolescent idiopathic scoliosis (AIS) and controls. Eating behavioral disorders, endocrine disorders, abnormal growth pattern and osteopenia have been well documented in AIS. Ghrelin is an orexigenic hormone produced by the stomach which reflects body weight changes and stimulates growth hormone secretion. Recently, it has been shown to be associated with bone metabolism and eating behavior. However, the circulating levels of ghrelin have never been evaluated in AIS patients.
Forty nine AIS girls and 15 controls were included. Anthropometric parameters and fasting circulating total ghrelin were measured. Curve severity was evaluated in AIS girls. The relationships between ghrelin and age, body weight, height, body mass index (BMI), BMI Z-score and corrected anthropometric parameters were analyzed in AIS girls and controls.
There was no significant difference in body weight, height, BMI or BMI Z-score between AIS and controls. Serum ghrelin level was 1.8 fold higher in AIS girls than in controls. Elevation of ghrelin levels remained significant when corrected BMI or corrected BMI Z-score were considered. Unlike in controls, positive correlations were found between ghrelin and age in AIS girls with a gradual increase of circulating ghrelin with age.
We have observed significantly higher circulating ghrelin levels in AIS than in controls with a positive correlation with age. This pilot-study suggests that ghrelin signaling might play a role in the initiation or development of AIS. Further studies are needed to validate theses results.
设计了一项对照研究，以调查青少年特发性脊柱侧凸（AIS）女孩及对照者的循环胃饥饿素水平。AIS患者存在饮食行为障碍、内分泌紊乱、异常生长模式和骨质减少等情况，已有充分记录。胃饥饿素是一种由胃产生的促食欲激素，反映体重变化并刺激生长激素分泌。最近研究表明，它与骨代谢和饮食行为有关。然而，从未对AIS患者的循环胃饥饿素水平进行评估。
纳入49名AIS女孩和15名对照者。测量人体测量参数和空腹循环总胃饥饿素水平。对AIS女孩的侧弯严重程度进行评估。分析AIS女孩和对照者中胃饥饿素与年龄、体重、身高、体重指数（BMI）、BMI Z评分及校正人体测量参数之间的关系。
AIS患者与对照者在体重、身高、BMI或BMI Z评分方面无显著差异。AIS女孩的血清胃饥饿素水平比对照者高1.8倍。在考虑校正BMI或校正BMI Z评分时，胃饥饿素水平的升高仍具有显著性。与对照者不同，在AIS女孩中发现胃饥饿素与年龄呈正相关，且循环胃饥饿素水平随年龄逐渐升高。
我们观察到AIS患者的循环胃饥饿素水平显著高于对照者，且与年龄呈正相关。这项初步研究表明，胃饥饿素信号通路可能在AIS的发生或发展中起作用。需要进一步研究来验证这些结果。
