Gong Xiaohua, Zhou Qi, Wang Fang, Wu Wenjun, Chen Xiaojun
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, Zhejiang 325015, China.
Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, Zhejiang 325015, China.
Int J Endocrinol. 2017;2017:8043429. doi: 10.1155/2017/8043429. Epub 2017 May 31.
To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating cystic thyroid nodules.
A total of 158 cystic or predominantly cystic thyroid nodules (>80% cystic component) in 143 patients were evaluated. 114 patients with compressive symptoms or aesthetic complaints were offered PPI. 44 individuals without compressive symptoms and aesthetic complaints who were only followed up clinically were used as the control group. The efficacy and safety of PPI were evaluated for 1 month, 3 months, 6 months, 9 months, and 12 months of follow-up.
In the PPI group, the mean baseline volume of 15.6 ± 18.9 cm reduced at the 1-month follow-up to 5.1 ± 5.6 cm ( < 0.001) and 0.6 ± 0.9 ( < 0.001), and nodules shrunk according to the time after PPI ( < 0.001). A complete response (if ≥70% decrease) to PPI at the 12-month follow-up occurred in 100% of the cystic or predominant cystic nodules. None of the nodules recurred at the 12-month follow-up after PPI. The side effects were mild. Twenty patients (17.5%) developed mild localized pain, and fourteen cases (12.3%) experienced mild or moderate fever after PPI.
PPI is a safe and effective alternative to treat benign cystic or predominant cystic thyroid nodules.
评估经皮聚多卡醇注射（PPI）治疗甲状腺囊性结节的有效性和安全性。
对143例患者的158个甲状腺囊性或主要为囊性结节（囊性成分>80%）进行评估。114例有压迫症状或美观问题的患者接受了PPI治疗。44例无压迫症状和美观问题且仅接受临床随访的患者作为对照组。在随访1个月、3个月、6个月、9个月和12个月时评估PPI的有效性和安全性。
在PPI组中，15.6±18.9cm的平均基线体积在1个月随访时降至5.1±5.6cm（<0.001），在12个月随访时降至0.6±0.9cm（<0.001），结节根据PPI后的时间而缩小（<0.001）。在12个月随访时，100%的囊性或主要为囊性结节对PPI有完全反应（如果减少≥70%）。PPI后12个月随访时无结节复发。副作用轻微。20例患者（17.5%）出现轻度局部疼痛，14例患者（12.3%）在PPI后出现轻度或中度发热。
PPI是治疗良性甲状腺囊性或主要为囊性结节的一种安全有效的替代方法。
