Myneni Ajay A, Chang Shen-Chih, Niu Rungui, Liu Li, Zhao Baoxing, Shi Jianping, Han Xiaoyou, Li Jiawei, Su Jia, Yu Shunzhang, Zhang Zuo-Feng, Mu Lina
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York (SUNY) at Buffalo, Buffalo, NY, United States.
Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), Los Angeles, CA, United States.
Front Public Health. 2017 Jun 8;5:102. doi: 10.3389/fpubh.2017.00102. eCollection 2017.
The ataxia telangiectasia-mutated () gene has a key role in DNA repair including activation and stabilization of , which implicates the importance of polymorphisms in the development of cancer. This study aims to investigate the association of two single-nucleotide polymorphisms (SNPs) with lung cancer, as well as their potential interaction with gene and other known risk factors of lung cancer.
A population-based case-control study was conducted in Taiyuan city, China with 399 cases and 466 controls matched on the distribution of age and sex of cases. The two gene SNPs, rs227060 and rs228589 as well as gene SNP, rs1042522 were genotyped using Sequenom platform. Unconditional logistic regression models were used to estimate crude and adjusted odds ratios (aOR) and 95% confidence intervals (CIs). Adjusted models controlled for age, sex, and smoking status.
The study showed that TT genotype of rs227060 (aOR = 1.58, 95% CI: 1.06-2.35) and AA genotype of rs228589 were significantly associated with lung cancer (aOR = 1.50, 95% CI: 1.08-2.08) in a recessive model. Additionally, carrying variant genotypes of rs227060 (TT), rs228589 (AA), and rs1042522 (CC) concomitantly was associated with much higher risk (aOR = 3.68, 95% CI: 1.43-9.45) of lung cancer than carrying variant genotypes of any one of the above three SNPs. We also found multiplicative and additive interaction between tea drinking and rs227060 in association with lung cancer.
This study indicates that gene variants might be associated with development of lung cancer in Chinese population. These results need to be validated in larger and different population samples.
共济失调毛细血管扩张症突变（）基因在DNA修复中起关键作用，包括激活和稳定，这暗示了多态性在癌症发生中的重要性。本研究旨在探讨两个单核苷酸多态性（SNP）与肺癌的关联，以及它们与基因和其他已知肺癌危险因素的潜在相互作用。
在中国太原市进行了一项基于人群的病例对照研究，有399例病例和466例对照，对照在病例的年龄和性别分布上进行匹配。使用Sequenom平台对两个基因SNP，即rs227060和rs228589以及基因SNP，rs1042522进行基因分型。使用无条件逻辑回归模型估计粗比值比和调整后的比值比（aOR）以及95%置信区间（CI）。调整后的模型控制了年龄、性别和吸烟状况。
研究表明，在隐性模型中，rs227060的TT基因型（aOR = 1.58，95% CI：1.06 - 2.35）和rs228589的AA基因型与肺癌显著相关（aOR = 1.50，95% CI：1.08 - 2.08）。此外，同时携带rs227060（TT）、rs228589（AA）和rs1042522（CC）的变异基因型与肺癌风险（aOR = 3.68，95% CI：1.43 - 9.45）显著高于携带上述三个SNP中任何一个的变异基因型。我们还发现饮茶与rs227060在与肺癌的关联中存在相乘和相加相互作用。
本研究表明基因变异可能与中国人群肺癌的发生有关。这些结果需要在更大和不同的人群样本中进行验证。
