Li Yanli, Chang Shen-Chih, Niu Rungui, Liu Li, Crabtree-Ide Christina R, Zhao Baoxing, Shi Jianping, Han Xiaoyou, Li Jiawei, Su Jia, Cai Lin, Yu Shunzhang, Zhang Zuo-Feng, Mu Lina
Department of Social and Preventive Medicine, School of Public Health and Health Professions, The State University of New York (SUNY) at Buffalo, 273A Farber Hall, Buffalo, New York 14214-8001, USA.
BMC Cancer. 2013 Dec 27;13:607. doi: 10.1186/1471-2407-13-607.
A pathway-based genotyping analysis suggested rs2078486 was a novel TP53 SNP, but very few studies replicate this association. TP53 rs1042522 is the most commonly studied SNP, but very few studies examined its potential interaction with environmental factors in relation to lung cancer risk. This study aims to examine associations between two TP53 single-nucleotide polymorphisms (SNPs) (rs2078486, rs1042522), their potential interaction with environmental factors and risk of lung cancer.
A case-control study was conducted in Taiyuan, China. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Multiplicative and additive interactions between TP53 SNPs and lifestyle factors were evaluated.
Variant TP53 rs2078486 SNP was significantly associated with elevated lung cancer risk among smokers (OR: 1.70, 95% CI: 1.08 - 2.67) and individuals with high indoor air pollution exposure (OR: 1.51, 95% CI: 1.00-2.30). Significant or borderline significant multiplicative and additive interactions were found between TP53 rs2078486 polymorphism with smoking and indoor air pollution exposure. The variant genotype of TP53 SNP rs1042522 significantly increased lung cancer risk in the total population (OR: 1.57, 95% CI: 1.11-2.21), but there was no evidence of heterogeneity among individuals with different lifestyle factors.
This study confirmed that TP53 rs2078486 SNP is potentially a novel TP53 SNP that may affect lung cancer risk. Our study also suggested potential synergetic effects of TP53 rs2078486 SNP with smoking and indoor air pollution exposure on lung cancer risk.
一项基于通路的基因分型分析表明，rs2078486是一种新的TP53单核苷酸多态性（SNP），但很少有研究重复这种关联。TP53 rs1042522是研究最广泛的SNP，但很少有研究探讨其与环境因素在肺癌风险方面的潜在相互作用。本研究旨在探讨两个TP53单核苷酸多态性（SNP）（rs2078486、rs1042522）之间的关联、它们与环境因素的潜在相互作用以及肺癌风险。
在中国太原进行了一项病例对照研究。采用无条件逻辑回归估计比值比（OR）和95%置信区间（95%CI）。评估了TP53 SNP与生活方式因素之间的相乘和相加相互作用。
TP53 rs2078486 SNP变异与吸烟者（OR：1.70，95%CI：1.08 - 2.67）和室内空气污染暴露水平高的个体（OR：1.51，95%CI：1.00 - 2.30）的肺癌风险升高显著相关。发现TP53 rs2078486多态性与吸烟和室内空气污染暴露之间存在显著或临界显著的相乘和相加相互作用。TP53 SNP rs1042522的变异基因型在总体人群中显著增加了肺癌风险（OR：1.57，95%CI：1.11 - 2.21），但没有证据表明不同生活方式因素的个体之间存在异质性。
本研究证实TP53 rs2078486 SNP可能是一种影响肺癌风险的新的TP53 SNP。我们的研究还表明TP53 rs2078486 SNP与吸烟和室内空气污染暴露在肺癌风险方面存在潜在协同效应。
