Department of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Division of Transplantation Immunology, National Institute for Child Health and Development, Tokyo, Japan.
J Immunol Res. 2017;2017:5295164. doi: 10.1155/2017/5295164. Epub 2017 May 31.
The connection between gene polymorphisms of cytotoxic T-lymphocyte-associated protein 4 () and primary biliary cholangitis (PBC) is still vague and blurred. The purpose of this study is to precisely estimate the association of the polymorphisms of with the risk of PBC by using a meta-analysis.
PubMed and the Chinese National Knowledge Infrastructure (CNKI) database were used to search correlative literatures, and the documents which were about the relationships between the polymorphisms of (rs231775, rs231725, rs3087243, and rs5742909) and PBC were collected as of June 2016. The strength of correlation based on odds ratios (ORs) and its 95% confidence intervals (95%CIs) was computed by STATA.
Generally, in rs231775, a significant risk was found in G allele, the value of OR was 1.32, and its 95%CI was 1.19 to 1.47. The same situation was found in A allele of rs231725, the value of OR was 1.33, and its 95%CI was 1.22 to 1.45. As genotypic level, different genotypic models were also found to have obvious relevance with PBC in rs231775 and rs231725. No obvious connections were found in other SNPs.
This study indicated that the polymorphisms of rs231775 and rs231725 would be the risk factors of PBC.
细胞毒性 T 淋巴细胞相关蛋白 4（）基因多态性与原发性胆汁性胆管炎（PBC）之间的联系仍不明确和模糊。本研究的目的是通过荟萃分析精确评估与 PBC 风险相关的多态性。
使用 PubMed 和中国国家知识基础设施（CNKI）数据库搜索相关文献，并收集截至 2016 年 6 月关于与 PBC 相关的多态性（rs231775、rs231725、rs3087243 和 rs5742909）的文献。使用 STATA 计算基于比值比（ORs）及其 95％置信区间（95％CIs）的相关性强度。
总体而言，在 rs231775 中，G 等位基因存在显著的风险，OR 值为 1.32，95％CI 为 1.19 至 1.47。rs231725 的 A 等位基因也存在相同的情况，OR 值为 1.33，95％CI 为 1.22 至 1.45。在基因型水平上，还发现 rs231775 和 rs231725 的不同基因型与 PBC 也具有明显的相关性。在其他 SNPs 中未发现明显的相关性。
本研究表明，rs231775 和 rs231725 的多态性可能是 PBC 的危险因素。
