Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
Curr Top Microbiol Immunol. 2018;419:151-189. doi: 10.1007/82_2017_30.
At every step of their replication cycle influenza viruses depend heavily on their host cells. The multifaceted interactions that occur between the virus and its host cell determine the outcome of the infection, including efficiency of progeny virus production, tropism, and pathogenicity. In order to understand viral disease and develop therapies for influenza it is therefore pertinent to study the intricate interplay between influenza viruses and their required host factors. Here, we review the current knowledge on host cell factors required by influenza virus at the different stages of the viral replication cycle. We also discuss the roles of host factors in zoonotic transmission of influenza viruses and their potential for developing novel antivirals.
在复制周期的每一步，流感病毒都严重依赖宿主细胞。病毒与其宿主细胞之间发生的多方面相互作用决定了感染的结果，包括子代病毒产生的效率、趋向性和致病性。因此，为了了解病毒性疾病并开发流感治疗方法，研究流感病毒与其所需宿主因子之间的复杂相互作用是很有必要的。在这里，我们综述了流感病毒在复制周期的不同阶段所需的宿主细胞因子的现有知识。我们还讨论了宿主因子在流感病毒的人畜共患病传播中的作用及其开发新型抗病毒药物的潜力。
