Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, Oklahoma, USA.
Lundberg-Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, USA.
RNA Biol. 2021 May;18(5):767-784. doi: 10.1080/15476286.2021.1872170. Epub 2021 Jan 18.
Influenza virus infection through seasonal epidemics and occasional pandemics has been a major public health concern for decades. Incomplete protection from vaccination and increased antiviral resistance due to frequent mutations of influenza viruses have led to a continuous need for new therapeutic options. The functional significance of host protein and influenza virus interactions has been established, but relatively less is known about the interaction of host noncoding RNAs, including microRNAs and long noncoding RNAs, with influenza viruses. In this review, we summarize host noncoding RNA profiles during influenza virus infection and the regulation of influenza virus infection by host noncoding RNAs. Influenza viral non-coding RNAs are briefly discussed. Increased understanding of the molecular regulation of influenza viral replication will be beneficial in identifying potential therapeutic targets against the influenza virus.
流感病毒通过季节性流行和偶尔的大流行感染，几十年来一直是主要的公共卫生关注点。由于流感病毒频繁突变，疫苗的保护作用不完全，抗病毒药物的耐药性增加，这导致了对新治疗选择的持续需求。宿主蛋白与流感病毒相互作用的功能意义已经确立，但相对较少的是关于宿主非编码 RNA（包括 microRNAs 和长非编码 RNA）与流感病毒相互作用的知识。在这篇综述中，我们总结了流感病毒感染期间宿主非编码 RNA 的特征，以及宿主非编码 RNA 对流感病毒感染的调节。简要讨论了流感病毒的非编码 RNA。增加对流感病毒复制的分子调控的理解将有助于确定针对流感病毒的潜在治疗靶点。
