Pelletier Jesse S, Capriotti Kara, Stewart Kevin S, Capriotti Joseph A
Ocean Ophthalmology Group, N. Miami Beach, FL, USA.
Plessen Ophthalmology Consultants, PO Box 910, Christiansted, USVI, USA.
Ophthalmol Ther. 2017 Dec;6(2):361-366. doi: 10.1007/s40123-017-0097-3. Epub 2017 Jun 22.
Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis.
A 95-year-old female presented with chronic blepharitis involving both the anterior and posterior eyelid margins. The anterior eyelid margins demonstrated pathognomonic features consistent with Demodex infection, and this diagnosis was confirmed with microscopy. Previous traditional therapies had been ineffective at controlling her signs and symptoms.
The topical PVP-I/DMSO system was effective at treating the signs and symptoms of Demodex blepharitis. Further investigation of the novel agent is warranted.
聚维酮碘水溶液是眼科常用的一种用于治疗眼表疾病的防腐剂。二甲基亚砜（DMSO）是一种著名的皮肤渗透促进剂，在眼科药物制剂中很少使用。我们在此描述一种含DMSO的凝胶中0.25%聚维酮碘的低剂量制剂，用于治疗睑缘蠕形螨睑缘炎。
一名95岁女性患有累及眼睑前后缘的慢性睑缘炎。眼睑前缘表现出与蠕形螨感染一致的特征性表现，显微镜检查证实了这一诊断。既往传统治疗方法未能有效控制其体征和症状。
局部应用聚维酮碘/二甲基亚砜系统对治疗蠕形螨睑缘炎的体征和症状有效。有必要对这种新型药物进行进一步研究。
