欧洲多发性硬化症负担与成本的新见解：俄罗斯的结果

New insights into the burden and costs of multiple sclerosis in Europe: Results for Russia.

作者信息

Boyko Alexey, Kobelt Gisela, Berg Jenny, Boyko Olga, Popova Ekaterina, Capsa Daniela, Eriksson Jennifer

机构信息

Pirogov Russian National Research Medical University, Moscow, Russia.

European Health Economics, Mulhouse, France.

出版信息

Mult Scler. 2017 Aug;23(2_suppl):155-165. doi: 10.1177/1352458517708668.

DOI:10.1177/1352458517708668

PMID:28643590

Abstract

BACKGROUND

In order to assess the value of management strategies in multiple sclerosis (MS), outcome data have to be combined with cost data. This, in turn, requires that cost data be regularly updated.

OBJECTIVE AND METHODS

This study is part of a cross-sectional retrospective study in 16 countries collecting current data on resource consumption, work capacity and health-related quality of life (HQoL). Descriptive analyses are presented by level of severity; costs are estimated in the societal perspective, in RUB 2015.

RESULTS

A total of 208 patients (mean age: 38.5 years) participated in the Russian study; 97% were below retirement age, and of these, 49% were employed. MS was reported to affect productivity at work in 63% of patients. Overall, 87% and 41% of patients felt that fatigue and cognition were a problem. The mean utility and costs were 0.769 and 578,000 RUB at Expanded Disability Status Scale (EDSS) 0-3, 0.509 and 826,000 RUB at EDSS 4-6.5, and 0.071 and 1,013,000 RUB at EDSS 7-9. The average cost of a relapse was 33,000 RUB.

CONCLUSION

This study illustrates the burden of MS on Russian patients and provides current data that are important for developing health policies.

摘要

背景

为了评估多发性硬化症（MS）管理策略的价值，必须将结果数据与成本数据相结合。这反过来又要求定期更新成本数据。

目的和方法

本研究是一项在16个国家开展的横断面回顾性研究的一部分，收集有关资源消耗、工作能力和健康相关生活质量（HQoL）的当前数据。按严重程度水平进行描述性分析；从社会角度以2015年卢布估算成本。

结果

共有208名患者（平均年龄：38.5岁）参与了俄罗斯的这项研究；97%未达到退休年龄，其中49%受雇工作。据报告，63%的患者MS影响工作效率。总体而言，87%和41%的患者认为疲劳和认知是问题。在扩展残疾状态量表（EDSS）0 - 3级时，平均效用和成本分别为0.769和578,000卢布，在EDSS 4 - 6.5级时为0.509和826,000卢布，在EDSS 7 - 9级时为0.071和1,013,000卢布。一次复发的平均成本为33,000卢布。