Sá Maria José, Kobelt Gisela, Berg Jenny, Capsa Daniela, Dalén Johan
Department of Neurology, Centro Hospitalar de S. João, Porto, Portugal.
European Health Economics, Mulhouse, France.
Mult Scler. 2017 Aug;23(2_suppl):143-154. doi: 10.1177/1352458517708667.
In order to assess the value of management strategies in multiple sclerosis (MS), outcome data have to be combined with cost data. This, in turn, requires that cost data be regularly updated.
This study is part of a cross-sectional retrospective study in 16 countries collecting current data on resource consumption, work capacity and health-related quality of life (HRQoL). Descriptive analyses are presented by level of severity; costs are estimated in the societal perspective, in EUR 2015.
A total of 535 patients (mean age 48.5 years) participated; 92% were below retirement age and of these, 43% were employed. Employment was related to disease severity, and MS was felt to affect productivity at work by 72% of patients, most often through fatigue. Overall, 98% and 74% of patients felt that fatigue and cognition were a problem. Mean utility and costs were 0.756 and €16,500 at the Expanded Disability Status Scale (EDSS) 0-3, 0.572 and €28,700 at EDSS 4-6.5 and 0.206 and €34,400 at EDSS 7-9. The average cost of a relapse was estimated at €2930.
This study illustrates the burden of MS on Portuguese patients and provides current data that are important for the development of health policies.
为了评估多发性硬化症（MS）管理策略的价值，必须将结果数据与成本数据相结合。这反过来又要求定期更新成本数据。
本研究是一项在16个国家开展的横断面回顾性研究的一部分，收集有关资源消耗、工作能力和健康相关生活质量（HRQoL）的当前数据。按严重程度水平进行描述性分析；从社会角度估算成本，以2015年欧元计。
共有535名患者（平均年龄48.5岁）参与；92%未到退休年龄，其中43%有工作。就业与疾病严重程度相关，72%的患者认为MS会影响工作效率，最常见的原因是疲劳。总体而言，98%和74%的患者认为疲劳和认知是问题。扩展残疾状态量表（EDSS）0 - 3级时，平均效用和成本分别为0.756和16,500欧元；EDSS 4 - 6.5级时为0.572和28,700欧元；EDSS 7 - 9级时为0.206和34,400欧元。复发的平均成本估计为2930欧元。
本研究说明了MS给葡萄牙患者带来的负担，并提供了对卫生政策制定很重要的当前数据。
