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妇科癌症中的血小板增多症

Thrombocytosis in gynecological cancers.

作者信息

Sharma Deepti, Singh Garima

机构信息

Department of Radiation Oncology, VMMC and Safdarjung Hospital, New Delhi, India.

出版信息

J Cancer Res Ther. 2017 Apr-Jun;13(2):193-197. doi: 10.4103/0973-1482.189234.

DOI:10.4103/0973-1482.189234
PMID:28643732
Abstract

Thrombocytosis has been suggested to be a poor prognostic indicator in malignancies. Studies have shown that thrombocytosis is associated with a poor prognosis in various gynecological malignancies such as carcinoma ovary, cervical cancer, and endometrial cancer. The aim of this study is to analyze the impact of thrombocytosis on the prognosis of gynecological cancer. All the relevant data were retrieved by PubMed, MEDLINE, and Web of Science, and then studies were chosen in this analysis of association between thrombocytosis and gynecological malignancy. Thrombocytosis is common in advanced disease in patients with ovarian cancer, endometrial cancer, and cervical cancer. Therefore, it may be a marker of tumor burden or biologically more aggressive disease. Thrombocytosis is bad prognostic factor and associated with poorer outcomes.

摘要

血小板增多症被认为是恶性肿瘤预后不良的指标。研究表明,血小板增多症与多种妇科恶性肿瘤(如卵巢癌、宫颈癌和子宫内膜癌)的预后不良有关。本研究的目的是分析血小板增多症对妇科癌症预后的影响。所有相关数据通过PubMed、MEDLINE和科学网检索,然后选择这些研究来分析血小板增多症与妇科恶性肿瘤之间的关联。血小板增多症在卵巢癌、子宫内膜癌和宫颈癌患者的晚期疾病中很常见。因此,它可能是肿瘤负荷或生物学上更具侵袭性疾病的标志物。血小板增多症是不良预后因素,与较差的结局相关。

相似文献

1
Thrombocytosis in gynecological cancers.妇科癌症中的血小板增多症
J Cancer Res Ther. 2017 Apr-Jun;13(2):193-197. doi: 10.4103/0973-1482.189234.
2
Preoperative elevated platelet count and thrombocytosis in gynecologic malignancies.妇科恶性肿瘤患者术前血小板计数升高与血小板增多症
Arch Gynecol Obstet. 2017 Jan;295(1):9-15. doi: 10.1007/s00404-016-4212-9. Epub 2016 Oct 6.
3
Thrombocytosis in gynecologic malignancies.妇科恶性肿瘤中的血小板增多症。
Anticancer Res. 2004 May-Jun;24(3b):2053-9.
4
Is thrombocytosis a valid indicator of advanced stage and high mortality of gynecological cancer?血小板增多症是妇科癌症晚期和高死亡率的有效指标吗?
Gynecol Oncol. 2015 Nov;139(2):312-8. doi: 10.1016/j.ygyno.2015.09.017. Epub 2015 Sep 25.
5
The association of preoperative thrombocytosis with prognostic factors in malign ovarian tumor.
Eur J Gynaecol Oncol. 2010;31(5):514-6.
6
Pretreatment thrombocytosis as a prognostic factor in women with gynecologic malignancies: a meta-analysis.预处理血小板增多症作为妇科恶性肿瘤女性患者的预后因素:一项荟萃分析。
Asian Pac J Cancer Prev. 2012;13(12):6077-81. doi: 10.7314/apjcp.2012.13.12.6077.
7
Beta-core fragment (beta-core/UGF/UGP), a tumor marker: a 7-year report.β核心片段(β核心/UGF/UGP),一种肿瘤标志物:一份7年的报告。
Gynecol Oncol. 1996 Feb;60(2):264-70. doi: 10.1006/gyno.1996.0036.
8
The pretreatment thrombocytosis as one of prognostic factors for gastric cancer: A systematic review and meta-analysis.预处理血小板增多症作为胃癌的预后因素之一:系统评价和荟萃分析。
Int J Surg. 2018 May;53:304-311. doi: 10.1016/j.ijsu.2018.03.084. Epub 2018 Apr 11.
9
Thrombocytosis as a prognostic factor in endometrial carcinoma.血小板增多症作为子宫内膜癌的一个预后因素。
Gynecol Oncol. 1998 Aug;70(2):210-4. doi: 10.1006/gyno.1998.5078.
10
Thrombocytosis in advanced epithelial ovarian cancer.晚期上皮性卵巢癌中的血小板增多症。
J Med Assoc Thai. 2007 Aug;90(8):1495-500.

引用本文的文献

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Investigation of the Relationship between Endometrial Cancer and Liver Fibrosis-4 Score.子宫内膜癌与肝脏纤维化-4评分之间关系的研究
Gynecol Minim Invasive Ther. 2025 Apr 10;14(2):118-124. doi: 10.4103/gmit.gmit_19_24. eCollection 2025 Apr-Jun.
2
Hematological changes in women with cervical cancer before and after cancer treatment: retrospective cohort study.宫颈癌治疗前后女性血液学变化:回顾性队列研究。
Sci Rep. 2024 Nov 12;14(1):27630. doi: 10.1038/s41598-024-75937-6.
3
Is There a Correlation Between Platelet Count, Mesenteric Lymph Node Involvement, and Hematogenous Metastases in Advanced Stage Ovarian Cancer?
晚期卵巢癌中血小板计数、肠系膜淋巴结受累与血行转移之间是否存在相关性?
In Vivo. 2024 Nov-Dec;38(6):2945-2954. doi: 10.21873/invivo.13777.
4
Dihydroartemisinin and its anticancer activity against endometrial carcinoma and cervical cancer: involvement of apoptosis, autophagy and transferrin receptor.双氢青蒿素及其对子宫内膜癌和宫颈癌的抗癌活性:涉及细胞凋亡、自噬和转铁蛋白受体。
Singapore Med J. 2021 Feb;62(2):96-103. doi: 10.11622/smedj.2019138. Epub 2019 Nov 4.
5
Preoperative SCC-Ag and thrombocytosis as predictive markers for pelvic lymphatic metastasis of squamous cervical cancer in early FIGO stage.术前鳞状细胞癌抗原(SCC-Ag)和血小板增多症作为FIGO早期宫颈癌盆腔淋巴结转移的预测标志物。
J Cancer. 2018 Apr 18;9(9):1660-1666. doi: 10.7150/jca.24049. eCollection 2018.