Ahmadi Zainab, Currow David C, Ekström Magnus
aDivision of Respiratory Medicine & Allergology, Department of Clinical Sciences, Lund University, Lund, Sweden bImPACCT, Faculty of Health, University of Technology Sydney, Ultimo, New South Wales, Australia.
Curr Opin Support Palliat Care. 2017 Sep;11(3):159-164. doi: 10.1097/SPC.0000000000000282.
Supplemental oxygen improves survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxaemia, but the effect of oxygen therapy in mild or moderate hypoxaemia to reduce symptomatic chronic breathlessness remains unclear. This review provides an overview of recent evidence about the role of oxygen therapy for the relief of chronic breathlessness in advanced illness.
In COPD, a recent Cochrane review strengthens earlier findings regarding the positive effect of supplemental oxygen compared with air during exercise test in the training setting. The novel analysis of effect of oxygen therapy on quality of life (QoL) showed no clear effect. Short-burst oxygen therapy given before exercise had no effect and should not be used.
Supplemental oxygen during exercise has been shown to reduce breathlessness in patients with COPD who have no or mild hypoxaemia, but it is not clear whether the reduction in breathlessness shown in the laboratory setting translates into a clinically important benefit. Further studies are needed to establish this.
补充氧气可提高慢性阻塞性肺疾病（COPD）合并严重低氧血症患者的生存率，但氧疗对轻、中度低氧血症患者减轻慢性症状性呼吸困难的效果仍不明确。本综述概述了近期关于氧疗在晚期疾病中缓解慢性呼吸困难作用的证据。
在慢性阻塞性肺疾病中，最近一项Cochrane综述强化了早期研究结果，即在训练环境下运动测试期间，补充氧气与空气相比具有积极作用。对氧疗对生活质量（QoL）影响的新分析未显示出明显效果。运动前给予短疗程氧疗无效，不应使用。
运动期间补充氧气已被证明可减轻无低氧血症或轻度低氧血症的慢性阻塞性肺疾病患者的呼吸困难，但尚不清楚实验室环境中显示的呼吸困难减轻是否转化为临床上的重要益处。需要进一步研究来证实这一点。
