Chua Mei Chin, Ben-Amor Kaouther, Lay Christophe, Neo Anne G E, Chiang Wei Chin, Rao Rajeshwar, Chew Charmaine, Chaithongwongwatthana Surasith, Khemapech Nipon, Knol Jan, Chongsrisawat Voranush
*KK Women's and Children's Hospital, Singapore †Danone Nutricia Research, Utrecht, The Netherlands ‡Danone Nutricia Research, Singapore §King Chulalongkorn Memorial Hospital ||Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand ¶Wageningen University, Wageningen, The Netherlands.
J Pediatr Gastroenterol Nutr. 2017 Jul;65(1):102-106. doi: 10.1097/MPG.0000000000001623.
We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P < 0.0001) until week 8 (P = 0.041), a reduction of Enterobacteriaceae from day 3/5 (P = 0.002) till week 12 (P = 0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.
我们确定了短链低聚半乳糖（scGOS）、长链低聚果糖（lcFOS）和短双歧杆菌M-16V对剖宫产出生婴儿肠道微生物群的影响。婴儿被随机分为三组，从出生到第16周分别接受标准配方奶粉（对照组）、添加scGOS/lcFOS和短双歧杆菌M-16V的配方奶粉（合生元组）或添加scGOS/lcFOS的配方奶粉（益生元组），另外纳入30名顺产婴儿作为参考组。与对照组相比，合生元组从第3/5天（P<0.0001）到第8周（P=0.041）双歧杆菌比例更高，从第3/5天（P=0.002）到第12周（P=0.016）肠杆菌科细菌数量减少。同时，粪便pH值降低，乙酸含量升高。在合生元组中，干预后6周，38.7%的婴儿检测到短双歧杆菌M-16V。这种合生元配方有助于早期调节剖宫产出生婴儿的双歧杆菌，这与模拟顺产婴儿的肠道生理环境有关。
