Ogburn P L, Hansen C A, Williams P P, Butler J C, Joseph M S, Julian T M
J Reprod Med. 1985 Aug;30(8):583-7.
Twenty-three patients in preterm labor failed to respond to single-agent tocolytic therapy or could not tolerate the dosage necessary to inhibit contractions. A combination of magnesium sulfate and ritodrine or terbutaline was used to inhibit labor in these patients. Fourteen patients (60.9%) responded to dual-agent tocolysis by delaying delivery for 48 hours or more. Six patients had delivery delayed for more than one week. Five patients had multiple gestations; three of them had delivery delayed more than 48 hours. Five patients developed pulmonary edema under treatment with dual-agent tocolysis; all responded to diuretic and/or oxygen therapy after the termination of tocolysis. Dual-agent tocolysis may significantly prolong some pregnancies complicated by preterm labor, but only at some risk to maternal well-being.
23例早产患者对单药宫缩抑制剂治疗无反应，或无法耐受抑制宫缩所需的剂量。在这些患者中，使用硫酸镁与利托君或特布他林联合用药来抑制宫缩。14例患者（60.9%）对双药宫缩抑制治疗有反应，分娩延迟48小时或更长时间。6例患者分娩延迟超过1周。5例患者为多胎妊娠；其中3例分娩延迟超过48小时。5例患者在双药宫缩抑制治疗过程中出现肺水肿；宫缩抑制治疗终止后，所有患者对利尿剂和/或氧疗均有反应。双药宫缩抑制治疗可能会显著延长一些并发早产的妊娠，但对母体健康有一定风险。
