Rodríguez-Violante Mayela, de Saráchaga Adib Jorge, Cervantes-Arriaga Amin, Davila-Avila Ned Merari, Carreón-Bautista Edith, Estrada-Bellmann Ingrid, Parra-López Guillermo, Cruz-Fino Diego, Pascasio-Astudillo Francisco
Clinical Neurodegenerative Research Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Movement Disorder Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Clinical Neurodegenerative Research Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Clin Neurol Neurosurg. 2017 Sep;160:46-49. doi: 10.1016/j.clineuro.2017.06.010. Epub 2017 Jun 15.
To assess the prevalence of pre-motor symptoms and estimate the risk for developing Parkinson's disease in Mexican population.
A case-control study was carried out with consecutive subjects with Parkinson's disease from two different referral centers in Mexico. Gender- and age-matched controls were randomly selected from the participating hospitals. All subjects were assessed using a structured questionnaire for the assessment of pre-motor symptoms (hyposmia, depression, anxiety, constipation, and sleep disorders). Odds ratios (OR) were calculated using logistic regression analysis.
A total of 430 subjects with PD and 430 healthy subjects were included. Premotor symptoms prevalence was 77.7% (n=334) for the PD group, compared to 41.3% (n=178) in the control group (p<0.001). After logistic multivariate analysis, previous history of hyposmia (OR 2.02 [95% CI 1.33-3.06]), depression (OR 2.52 [95% CI 1.67-3.84]), anxiety (OR 4.37 [95% CI 2.73-6.98]) and sleep disorders (OR 2.03 [95% CI 1.41-2.93]) were independently associated with Parkinson's disease. Overall prediction success of the model was 81.2% for controls and 61.2% for subjects with PD.
All five premotor symptoms assessed were more commonly reported in PD subjects than healthy controls. The presence of non-motor symptoms yield a prediction success of 71.2% to discriminate between PD subjects and healthy controls.
评估墨西哥人群中运动前症状的患病率，并估计患帕金森病的风险。
对来自墨西哥两个不同转诊中心的帕金森病连续患者进行了病例对照研究。从参与研究的医院中随机选取性别和年龄匹配的对照。所有受试者均使用结构化问卷进行运动前症状（嗅觉减退、抑郁、焦虑、便秘和睡眠障碍）评估。使用逻辑回归分析计算比值比（OR）。
共纳入430例帕金森病患者和430例健康受试者。帕金森病组运动前症状患病率为77.7%（n = 334），而对照组为41.3%（n = 178）（p < 0.001）。经过多因素逻辑分析，既往嗅觉减退史（OR 2.02 [95% CI 1.33 - 3.06]）、抑郁史（OR 2.52 [95% CI 1.67 - 3.84]）、焦虑史（OR 4.37 [95% CI 2.73 - 6.98]）和睡眠障碍史（OR 2.03 [95% CI 1.41 - 2.93]）与帕金森病独立相关。该模型对对照组的总体预测成功率为81.2%，对帕金森病患者为61.2%。
与健康对照组相比，帕金森病患者中报告的所有五种运动前症状更为常见。非运动症状的存在对区分帕金森病患者和健康对照组的预测成功率为71.2%。
