Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel Diseases, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel Diseases, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
Diabetes Res Clin Pract. 2017 Aug;130:154-162. doi: 10.1016/j.diabres.2017.05.013. Epub 2017 Jun 20.
To investigate the association of serum ferritin levels and ferritin level changes with the 10-year risk of new-onset type 2 diabetes mellitus (T2DM).
Among 2359 subjects without T2DM at baseline in 2002, 1956 subjects were re-examined in 2007, and 1660 subjects were invited to be re-examined in 2012. Serum ferritin (ng/ml) levels were measured by latex-enhanced turbidimetric immunoassay. Five-year serum ferritin changes were categorized into four groups using the median as the cut-off point. Multivariate logistic regression was performed to examine the independent association of serum ferritin levels and 5-year ferritin level changes with 10-year new-onset T2DM.
At the 10-year follow-up, 205 (12.3%) subjects had developed new-onset T2DM. After adjusting for traditional risk factors and high-sensitivity C-reactive protein, 10-year new-onset T2DM risk was significantly increased in subjects in the highest tertile of baseline serum ferritin levels [odds ratio (OR)=1.80, 95% confidence interval (CI): 1.17-2.79] and in subjects with high serum ferritin levels in both 2002 and 2007 (OR=1.54, 95% CI: 1.01-2.34). After adjusting for baseline fasting blood glucose, the effect was attenuated and became borderline or non-significant.
Serum ferritin levels and ferritin level changes were associated with 10-year new-onset T2DM risk in the Chinese population, whereas the independent effect awaits validation from studies with larger sample sizes.
探讨血清铁蛋白水平及其变化与新发 2 型糖尿病（T2DM）10 年发病风险的关系。
在 2002 年无 T2DM 的 2359 例受试者中，1956 例于 2007 年再次接受检查，1660 例受邀于 2012 年再次接受检查。采用乳胶增强比浊免疫法检测血清铁蛋白（ng/ml）水平。以中位数为界点，将 5 年血清铁蛋白变化分为四组。采用多因素 logistic 回归分析血清铁蛋白水平及 5 年铁蛋白水平变化与 10 年新发 T2DM 的独立相关性。
在 10 年随访中，205 例（12.3%）受试者发生新发 T2DM。在调整传统危险因素和高敏 C 反应蛋白后，基线血清铁蛋白水平最高三分位的受试者发生新发 T2DM 的风险显著增加[比值比（OR）=1.80，95%置信区间（CI）：1.17-2.79]，2002 年和 2007 年血清铁蛋白水平均较高的受试者发生新发 T2DM 的风险也显著增加[OR=1.54，95%CI：1.01-2.34]。调整基线空腹血糖后，其作用减弱且呈边缘或无统计学意义。
血清铁蛋白水平及其变化与中国人群新发 T2DM 风险相关，但其独立作用尚待大样本量研究验证。
