血清铁蛋白浓度升高与中国人群 2 型糖尿病发病风险相关：一项前瞻性队列研究。
Elevated serum ferritin concentration is associated with incident type 2 diabetes mellitus in a Chinese population: A prospective cohort study.
机构信息
Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China.
Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China; Department of Endocrinology and Metabolism, Pinggu Hospital, The 59th Xinping North Road, Pinggu, Beijing, China.
出版信息
Diabetes Res Clin Pract. 2018 May;139:155-162. doi: 10.1016/j.diabres.2018.03.001. Epub 2018 Mar 8.
AIMS
We aimed to evaluate the association between serum ferritin levels and incident type 2 diabetes mellitus risk in a Chinese population.
METHODS
This cohort study assessed 2225 Chinese individuals aged 25-75 years. Diabetes mellitus was diagnosed using the 1999 World Health Organization definition with a median follow-up period of 20 months. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals (CI) for incident diabetes when serum ferritin concentrations increased by one standard deviation.
RESULTS
During the follow-up period, 112 cases (62 men and 50 women) of type 2 diabetes mellitus were identified. Baseline serum ferritin levels were higher in the diabetes than the non-diabetes group. After adjusting for age, body mass index, waist circumference, mean arterial pressure, fasting plasma glucose, fasting insulin, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, alanine transaminase and triglyceride levels, family history of diabetes mellitus, pork meat consumption, neutrophil/lymphocyte ratio, education, and annual household income, the hazard ratios for incident diabetes corresponding to one standard deviation increase in serum ferritin levels were 1.17 (95% CI 1.03, 1.34), 1.20 (95% CI 1.003, 1.43), and 1.03 (95% CI 0.82, 1.31) for the total population, men, and women, respectively.
CONCLUSIONS
High serum ferritin levels were associated with a higher risk of incident type 2 diabetes mellitus independent of traditional risk factors in the total population and men.
目的
我们旨在评估中国人群血清铁蛋白水平与 2 型糖尿病发病风险之间的关系。
方法
本队列研究评估了 2225 名年龄在 25-75 岁的中国个体。糖尿病的诊断采用 1999 年世界卫生组织的定义，中位随访时间为 20 个月。使用 Cox 比例风险模型估计血清铁蛋白浓度增加一个标准差时发生糖尿病的校正危险比和 95%置信区间（CI）。
结果
在随访期间，确定了 112 例（62 名男性和 50 名女性）2 型糖尿病病例。糖尿病组的基线血清铁蛋白水平高于非糖尿病组。在校正年龄、体重指数、腰围、平均动脉压、空腹血糖、空腹胰岛素、糖化血红蛋白、总胆固醇、高密度脂蛋白胆固醇、丙氨酸转氨酶和甘油三酯水平、糖尿病家族史、猪肉消费、中性粒细胞/淋巴细胞比值、教育程度和年家庭收入后，血清铁蛋白水平每增加一个标准差与新发糖尿病的风险比分别为 1.17（95%CI 1.03，1.34）、1.20（95%CI 1.003，1.43）和 1.03（95%CI 0.82，1.31），适用于总体人群、男性和女性。
结论
高血清铁蛋白水平与总体人群和男性中传统危险因素之外的 2 型糖尿病发病风险增加相关。
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