Huang Jizhen, Wang Zhiwei, Hu Zhipeng, Jiang Wanli, Li Bowen
Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Clin Chim Acta. 2017 Aug;471:270-275. doi: 10.1016/j.cca.2017.06.018. Epub 2017 Jun 20.
The association between blood vitamin D levels and the risk of myocardial infarction (MI) is controversial. This meta-analysis aimed to describe the relationship between MI risk and blood vitamin D levels.
Online databases were searched in PubMed, EMBASE and Web of science till February 2017 for observational studies in relation to reporting the vitamin D levels in MI cases and non-MI controls. The weighted mean difference (WMD) or odds ratio (OR), with 95% confidence interval (CI), were calculated to evaluate the relationship between MI risk and blood vitamin D levels.
Eight observational studies with 9913 individuals, consisted of 3411 MI patients and 6502 non-MI controls, were included in our study. The pooled results revealed that blood vitamin D levels were significantly lower in MI patients when compared with non-MI controls (WMD=-3.40; 95% CI: -5.87 to -0.92, P=0.007). Subgroup analyses indicated MI patients were also associated with lower levels of blood vitamin D in America and Asia. Furthermore, when compared to non-MI controls, sufficient blood vitamin D appeared to protect against the occurrence of MI (OR=0.44; 95% CI: 0.25 to 0.76, P=0.004) in MI patients. Subgroup analyses also showed that sufficient blood 25(OH)D levels was a protective factor for MI in America and Asia.
Present study suggested that the levels of blood 25(OH)D were significant lower in MI patients, especially in America and Asia, and sufficient blood vitamin D levels might protect against the occurrence of MI.
血液维生素D水平与心肌梗死（MI）风险之间的关联存在争议。本荟萃分析旨在描述MI风险与血液维生素D水平之间的关系。
在PubMed、EMBASE和Web of science在线数据库中进行检索，直至2017年2月，以查找关于报告MI病例和非MI对照中维生素D水平的观察性研究。计算加权平均差（WMD）或比值比（OR）及95%置信区间（CI），以评估MI风险与血液维生素D水平之间的关系。
我们的研究纳入了8项观察性研究，共9913名个体，其中包括3411名MI患者和6502名非MI对照。汇总结果显示，与非MI对照相比，MI患者的血液维生素D水平显著更低（WMD = -3.40；95% CI：-5.87至-0.92，P = 0.007）。亚组分析表明，在美国和亚洲，MI患者的血液维生素D水平也较低。此外，与非MI对照相比，充足的血液维生素D似乎可预防MI患者发生MI（OR = 0.44；95% CI：0.25至0.76，P = 0.004）。亚组分析还显示，在美国和亚洲，充足的血液25(OH)D水平是MI的一个保护因素。
本研究表明，MI患者的血液25(OH)D水平显著更低，尤其是在美国和亚洲，而充足的血液维生素D水平可能预防MI的发生。
