van der Ven Myrthe, Luime Jolanda J, van der Velden Levinia L, Bosch Johan G, Hazes Johanna M W, Vos Hendrik J
Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands.
Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
Ultrasound Med Biol. 2017 Sep;43(9):1868-1879. doi: 10.1016/j.ultrasmedbio.2017.04.027. Epub 2017 Jun 20.
Early recognition of joint inflammation will increase treatment efficacy in rheumatoid arthritis (RA). Yet, conventional power Doppler (PD) ultrasound might not be sufficiently sensitive to detect minor inflammation. We investigated the sensitivity of high-frame rate Doppler, combined with singular value decomposition technique, to suppress tissue signals, for microvascular flow in a flow phantom setup and in a proof-of-principle study in healthy controls and in RA patients with different disease activities. In the flow phantom, minimal detectable flow velocity was a factor 3 lower with high-frame-rate PD than with conventional PD ultrasound. In the proof-of-principle study we detected a positive PD signal in all volunteers, diseased or healthy, with high-frame-rate PD ultrasound. We saw a gradual increase in PD signal in RA patients depending on disease activity. In conclusion, high-frame rate Doppler is more sensitive in detecting vascularisation than conventional PD ultrasound.
早期识别关节炎症可提高类风湿关节炎（RA）的治疗效果。然而，传统的能量多普勒（PD）超声可能对检测轻微炎症不够敏感。我们研究了高帧率多普勒结合奇异值分解技术抑制组织信号以检测流动模型设置以及健康对照和不同疾病活动度的RA患者的原理验证研究中微血管血流的敏感性。在流动模型中，高帧率PD的最小可检测流速比传统PD超声低3倍。在原理验证研究中，我们用高帧率PD超声在所有志愿者（患病或健康）中均检测到阳性PD信号。我们发现RA患者的PD信号随疾病活动度逐渐增加。总之，高帧率多普勒在检测血管化方面比传统PD超声更敏感。
