Versatility of presenilin 1.
作者信息
Frost Georgia R, Wong Eitan, Li Yue-Ming
机构信息
Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Program in Neurosciences, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021.
出版信息
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6885-6887. doi: 10.1073/pnas.1707809114. Epub 2017 Jun 23.
Abstract
摘要
相似文献
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Versatility of presenilin 1.早老素1的多功能性
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6885-6887. doi: 10.1073/pnas.1707809114. Epub 2017 Jun 23.
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本文引用的文献
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Bidirectional regulation of Aβ levels by Presenilin 1.早老素 1 对 Aβ 水平的双向调节。
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7142-7147. doi: 10.1073/pnas.1705235114. Epub 2017 May 22.
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Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.磷酸化早老素 1 通过促进自噬体-溶酶体融合来减少β-淀粉样蛋白。
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7148-7153. doi: 10.1073/pnas.1705240114. Epub 2017 May 22.
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Pathogenic PS1 phosphorylation at Ser367.致病性早老素1在丝氨酸367处的磷酸化。
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An atomic structure of human γ-secretase.人类γ-分泌酶的原子结构。
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5
Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.早老素-1基因敲入小鼠揭示了家族性阿尔茨海默病的功能丧失机制。
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Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.新的早老素-1磷酸化位点的鉴定：对γ-分泌酶活性和Aβ生成的影响。
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7
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.酪蛋白激酶1亚型的生物学功能及其在肿瘤发生中的假定作用。
Mol Cancer. 2014 Oct 11;13:231. doi: 10.1186/1476-4598-13-231.
8
Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.Hif-1α在乳腺癌中激活γ-分泌酶和Notch信号通路的非转录作用
Cell Rep. 2014 Aug 21;8(4):1077-92. doi: 10.1016/j.celrep.2014.07.028. Epub 2014 Aug 14.
9
Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide.自噬的双重作用：阿尔茨海默病Aβ肽的降解与分泌
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10
Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.衔接蛋白复合物 AP2/PICALM 通过与 LC3 相互作用，将阿尔茨海默病 APP-CTF 靶向到自噬体进行末端降解。
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17071-6. doi: 10.1073/pnas.1315110110. Epub 2013 Sep 25.
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