[Changes in the ultrastructure of synapses of neurons of the cerebral cortex of the rat in response to isolated and combined microapplications of mediators].

Presynaptic and postsynaptic ultrastructure components in the axo-dendritic synapses of layer V of the rat sensomotor cortex were compared after isolated and combined microionophoretical applications of 1-glutamate and noradrenaline. An increase in the width of the postsynaptic density was established in case of combined glutamate and noradrenaline applications. Both isolated and combined transmitter applications decreased the quantity of synaptic vesicles in the terminals. The data are considered as evidence of modulatory action of noradrenaline on other neurotransmitter systems.