Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic, Scottsdale, Arizona, USA.
Muscle Nerve. 2018 Mar;57(3):395-400. doi: 10.1002/mus.25732. Epub 2017 Jul 5.
We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions.
Fifty-eight patients with CINM who had been seen over a 17-year period were retrospectively studied. Electrodiagnostic findings of the CINM cohort were compared with patients with axonal peripheral neuropathy and myopathy due to other causes.
Mean CMAP durations were prolonged, and mean CMAP amplitudes were severely reduced both proximally and distally in all nerves studied in the CINM cohort relative to the control groups. The specificity of prolonged CMAP durations for CINM approached 100% if they were encountered in more than 1 nerve.
Prolonged, low-amplitude CMAPs occur more frequently and with greater severity in CINM patients than in neuromuscular controls with myopathy and axonal neuropathy and are highly specific for the diagnosis of CINM. Muscle Nerve 57: 395-400, 2018.
我们旨在确定在患有其他神经肌肉疾病的对照组中，与其他神经肌肉疾病相比，在患有大量危重病肌病（CINM）的患者中，复合肌肉动作电位（CMAP）的持续时间和幅度的特异性。
回顾性研究了在 17 年期间观察到的 58 例 CINM 患者。比较了 CINM 队列的电诊断发现与其他原因引起的轴索性周围神经病和肌病患者。
与对照组相比，在 CINM 队列中所有研究神经的 CMAP 持续时间均延长，近端和远端的 CMAP 幅度均严重降低。如果在 1 个以上的神经中遇到延长的 CMAP 持续时间，则 CINM 的特异性接近 100％。
与患有肌病和轴索性神经病的神经肌肉对照组相比，CINM 患者更频繁且更严重地出现延长，低幅度的 CMAP，并且高度特异性诊断为 CINM。肌肉神经 57：395-400，2018 年。
