Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling.
作者信息
Dawson Paul A
机构信息
Department of Pediatrics Division of Gastroenterology Hepatology and Nutrition Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.
出版信息
Hepatology. 2017 Nov;66(5):1384-1386. doi: 10.1002/hep.29325. Epub 2017 Sep 29.
Abstract
摘要
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本文引用的文献
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Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.在小鼠中，结合型胆汁酸的肝脏摄取由牛磺胆酸钠共转运多肽和有机阴离子转运多肽介导，并受血浆胆汁酸水平的肠道感知调节。
Hepatology. 2017 Nov;66(5):1631-1643. doi: 10.1002/hep.29251. Epub 2017 Sep 29.
2
NTCP deficiency and persistently raised bile salts: an adult case.牛磺胆酸钠共转运多肽缺乏与胆汁盐持续升高：一例成人病例
J Inherit Metab Dis. 2017 May;40(3):313-315. doi: 10.1007/s10545-017-0031-9. Epub 2017 Mar 10.
3
Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency.一名患有牛磺胆酸钠共转运多肽缺乏症的儿科患者的临床和分子研究。
Exp Ther Med. 2016 Nov;12(5):3294-3300. doi: 10.3892/etm.2016.3752. Epub 2016 Sep 27.
4
Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.在钠离子-牛磺胆酸盐共转运多肽基因敲除小鼠中，结合型胆汁酸摄取受损及乙肝病毒前S1结合受损。
Hepatology. 2015 Jul;62(1):207-19. doi: 10.1002/hep.27694. Epub 2015 May 8.
5
The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B.SLC10A1 中的 p.Ser267Phe 变异与慢性乙型肝炎的耐药性相关。
Hepatology. 2015 Apr;61(4):1251-60. doi: 10.1002/hep.27608. Epub 2015 Feb 23.
6
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype.牛磺胆酸钠共转运蛋白（SLC10A1）缺乏症：结合性高胆血症，无明显临床表型。
Hepatology. 2015 Jan;61(1):260-7. doi: 10.1002/hep.27240. Epub 2014 Aug 25.
7
Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.钠-牛磺胆酸盐共转运多肽（SLC10A1）的种族依赖性多态性揭示了对胆汁酸底物识别至关重要的结构域。
J Biol Chem. 2004 Feb 20;279(8):7213-22. doi: 10.1074/jbc.M305782200. Epub 2003 Dec 2.
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