Subbalakshmi G Y, Murthy C R
Neurosci Lett. 1985 Aug 16;59(1):121-6. doi: 10.1016/0304-3940(85)90225-3.
Activity levels of the enzymes of glutamate metabolism were determined in the neuronal perikarya and synaptosomes isolated from the cerebral cortex of normal and hyperammonemic rats. In neuronal perikarya, the activities of glutamate dehydrogenase, aspartate, alanine aminotransferases and glutamine synthetase were elevated in hyperammonemic states. In synaptosomes, glutamate dehydrogenase and aspartate aminotransferase were suppressed, while glutamine synthetase and glutaminase were elevated. These results suggested the involvement of neuronal perikarya in ammonia detoxification at least in acute hyperammonemic states.
在从正常大鼠和高氨血症大鼠大脑皮层分离出的神经元胞体和突触体中，测定了谷氨酸代谢酶的活性水平。在神经元胞体中，高氨血症状态下谷氨酸脱氢酶、天冬氨酸、丙氨酸转氨酶和谷氨酰胺合成酶的活性升高。在突触体中，谷氨酸脱氢酶和天冬氨酸转氨酶受到抑制，而谷氨酰胺合成酶和谷氨酰胺酶升高。这些结果表明，至少在急性高氨血症状态下，神经元胞体参与了氨的解毒过程。
