Tolle D V, Seed T M, Fritz T E, Lombard L S, Poole C M, Norris W P
Vet Pathol. 1979 Mar;16(2):243-54. doi: 10.1177/030098587901600210.
A purebred female Beagle dog that had received 2,000 R of protracted wholebody gamma-irradiation from 60Co when 14 months old had hematologic changes consistent with a myeloproliferative disorder 3 years after the termination of radiation exposure. Peripheral blood and bone marrow findings during the 7-month period before death showed progressive anemia with increased numbers of platelets; immature granulocytes, monocytes and promonocytes. A period of partial remission occurred during which time the peripheral blood was aleukemic, although there was marked thrombocytosis and abnormal erythropoiesis which was evidenced by bizarre circulating nucleated red cells, anisocytosis, poikilocytosis and Howell-Jolly bodies. The dog had a terminal crisis with marked leukocytosis, most cells in the peripheral blood being bizarre monocytes and promonocytes. Tissues obtained at necropsy showed diffuse as well as focal infiltration of the spleen, liver, lymph nodes, heart, kidney and gastrointestinal wall with immature neoplastic cells resembling monocytes and monocytic precursors. The monocytic differentiation of the invasive cell population was confirmed by morphological, cytochemical, histological, ultrastructural and in vitro cell culture studies.
一只纯种雌性比格犬在14个月大时接受了来自60Co的2000拉德全身长时间γ射线照射，在辐射暴露结束3年后出现了与骨髓增殖性疾病相符的血液学变化。死前7个月期间的外周血和骨髓检查结果显示进行性贫血，血小板数量增加；出现未成熟粒细胞、单核细胞和原单核细胞。出现了一段部分缓解期，在此期间外周血无白血病表现，尽管存在明显的血小板增多症和异常红细胞生成，表现为形态怪异的循环有核红细胞、红细胞大小不均、异形红细胞症和豪-焦小体。这只狗最终出现了严重的白细胞增多症危象，外周血中的大多数细胞是形态怪异的单核细胞和原单核细胞。尸检时获取的组织显示，脾脏、肝脏、淋巴结、心脏、肾脏和胃肠道壁出现弥漫性以及局灶性浸润，浸润细胞为类似单核细胞和单核细胞前体的未成熟肿瘤细胞。通过形态学、细胞化学、组织学、超微结构和体外细胞培养研究证实了浸润细胞群体的单核细胞分化。
