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苏丹患先兆子痫女性的母血抗苗勒管激素

Maternal serum anti-Müllerian hormone in Sudanese women with preeclampsia.

作者信息

Agabain Eiman, Mohamed Hameed, Elsheikh Anas E, Hamdan Hamdan Z, Adam Ishag

机构信息

Medical College, Qassim University, Buraydah, Kingdom of Saudi Arabia.

Faculty of Medicine, Alneelain University, Khartoum, Sudan.

出版信息

BMC Res Notes. 2017 Jun 24;10(1):217. doi: 10.1186/s13104-017-2544-6.

DOI:10.1186/s13104-017-2544-6
PMID:28646929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5483251/
Abstract

OBJECTIVES

A case-control study was conducted at Omdurman Maternity Tertiary Hospital, Sudan, during the period from May to August 2014 to investigate AMH level in women with preeclampsia compared to healthy controls. The cases were women with preeclampsia and healthy pregnant women were the controls. The obstetrics and medical history was gathered using a questionnaire. AMH level was measured using ELISA.

RESULTS

There was no significant difference between the two groups (40 in each arm of the study) in the age, parity and gestational age. Thirty-three of the 40 cases were patients with severe preeclampsia. There was no significant difference in median inter-quartile of the AMH level between the women with preeclampsia and the controls [0.700 (0.225-1.500) vs. 0.700 (0.400-1.275) ng/ml, P = 0.967]. In a linear regression model there was no association between the log of AMH and age, parity, gestational age, BMI, hemoglobin level and preeclampsia.

摘要

目的

2014年5月至8月期间,在苏丹恩图曼妇产三级医院开展了一项病例对照研究,以调查子痫前期女性与健康对照者的抗缪勒管激素(AMH)水平。病例为子痫前期女性,健康孕妇为对照。通过问卷收集产科和病史。使用酶联免疫吸附测定法(ELISA)测量AMH水平。

结果

两组(研究每组各40例)在年龄、产次和孕周方面无显著差异。40例病例中有33例为重度子痫前期患者。子痫前期女性与对照者之间AMH水平的中位数四分位数间距无显著差异[0.700(0.225 - 1.500)对0.700(0.400 - 1.275)ng/ml,P = 0.967]。在一个线性回归模型中,AMH的对数与年龄、产次、孕周、体重指数、血红蛋白水平和子痫前期之间无关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c807/5483251/247c9c08c882/13104_2017_2544_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c807/5483251/247c9c08c882/13104_2017_2544_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c807/5483251/247c9c08c882/13104_2017_2544_Fig1_HTML.jpg

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J Family Reprod Health. 2017 Dec;11(4):179-184.

本文引用的文献

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Ovarian reserve in women with a previous history of severe pre-eclampsia.有重度子痫前期病史女性的卵巢储备功能。
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May maternal anti-mullerian hormone levels predict adverse maternal and perinatal outcomes in preeclampsia?母体抗苗勒管激素水平能否预测子痫前期的不良母体和围产期结局?
J Matern Fetal Neonatal Med. 2015 Aug;28(12):1451-6. doi: 10.3109/14767058.2014.955007. Epub 2014 Sep 10.
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Maternal serum anti-Müllerian hormone at 11-13 weeks' gestation in the prediction of preeclampsia.孕11至13周时孕妇血清抗苗勒管激素对先兆子痫的预测作用
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Evaluation of anti-Mullerian hormone in the first trimester as a predictor for hypertensive disorders of pregnancy and other adverse pregnancy outcomes.孕早期抗苗勒管激素作为妊娠期高血压疾病及其他不良妊娠结局预测指标的评估
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Serum AMH levels in women with a history of preeclampsia suggest a role for vascular factors in ovarian aging.有先兆子痫病史的女性血清抗苗勒管激素(AMH)水平表明血管因素在卵巢衰老中起作用。
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Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy.妊娠期高血压。美国妇产科医师学会妊娠期高血压特别工作组报告
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