Jamil Zehra, Shahid Sana, Baig Erum, Ahmad Rida, Subhani Faryal, Fatima Syeda Sadia
Department of Biological & Biomedical Sciences, Aga Khan University, Pakistan.
Department of Physiology, Sir Syed College of Medical Sciences for Girls, Pakistan.
Taiwan J Obstet Gynecol. 2019 Mar;58(2):188-191. doi: 10.1016/j.tjog.2019.01.003.
The aim of the study was to explore the association of serum AMH and Renalase with the risk of preeclampsia thereby assessing them as screening tools, reducing the risk of gravid consequences of preeclampsia.
This cross-sectional study recruited n = 95 pregnant women between 14 and 32 gestational weeks. They were categorized as a) women with gestational hypertension (n = 45); b) women with pre-eclampsia (n = 20) and c) normotensive pregnant women (n = 30) according to the ACOG criteria. Anthropometrics data and blood and urine samples were collected. AMH and Renalase levels were measured by ELISA assay.
The mean age of study cohort was 27.3 ± 6.2 year and weight was 65.1 ± 14.1 kg. Blood pressures were significantly higher in pre-eclamptic patients versus both the gestational hypertensive females and controls (p < 0.05). AMH was found to be significantly higher in controls but no difference was observed between gestational hypertensive and pre-eclamptic patients. No difference was seen for serum Renalase among the three groups (p > 0.05). AMH showed a negative weak correlation with diastolic blood pressure (r = -0.272; p = 0.008) that remained significant even after adjustment (r = -0.236; p = 0.023) whereas Renalase did not show any difference (r = -0.051; p > 0.05). Females with low levels of AMH were 1.07 times at risk of developing hypertension even after adjustment for age and BMI (p < 0.05).
Low AMH levels may lead to hypertension in pregnancy suggesting a role in detecting vascular diseases as well as its effect on ovarian aging. However, further research is required to establish a causal relationship.
本研究旨在探讨血清抗缪勒管激素（AMH）和肾酶与子痫前期风险的相关性，从而将它们评估为筛查工具，降低子痫前期妊娠后果的风险。
这项横断面研究招募了95名妊娠14至32周的孕妇。根据美国妇产科医师学会（ACOG）标准，她们被分为以下三类：a）妊娠期高血压女性（n = 45）；b）子痫前期女性（n = 20）；c）血压正常的孕妇（n = 30）。收集人体测量数据以及血液和尿液样本。通过酶联免疫吸附测定（ELISA）法测量AMH和肾酶水平。
研究队列的平均年龄为27.3±6.2岁，体重为65.1±14.1千克。子痫前期患者的血压显著高于妊娠期高血压女性和对照组（p < 0.05）。发现对照组的AMH显著更高，但妊娠期高血压患者和子痫前期患者之间未观察到差异。三组之间血清肾酶无差异（p > 0.05）。AMH与舒张压呈负弱相关（r = -0.272；p = 0.008），即使在调整后仍具有显著性（r = -0.236；p = 0.023），而肾酶无差异（r = -0.051；p > 0.05）。即使在调整年龄和体重指数（BMI）后，AMH水平低的女性患高血压的风险仍为1.07倍（p < 0.05）。
低AMH水平可能导致妊娠期高血压，提示其在检测血管疾病以及对卵巢衰老的影响方面具有作用。然而，需要进一步研究以建立因果关系。
