Hempel Chris M, Werley Christopher A, Dempsey Graham T, Gerber David J
Q-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Q-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Drug Discov Today Technol. 2017 Mar;23:17-25. doi: 10.1016/j.ddtec.2017.03.005. Epub 2017 May 6.
There is a pressing need for new and more effective treatments for central nervous system (CNS) disorders. A large body of evidence now suggests that alterations in synaptic transmission and neuronal excitability represent underlying factors for many neurological and psychiatric diseases. However, it has been challenging to target these complex functional domains for therapeutic discovery using traditional neuronal assay methods. Here we review advances in neuronal screening technologies and cellular model systems that enable phenotypic screening of neuronal function as a basis for novel CNS drug discovery approaches.
对于中枢神经系统（CNS）疾病，迫切需要新的、更有效的治疗方法。现在大量证据表明，突触传递和神经元兴奋性的改变是许多神经和精神疾病的潜在因素。然而，使用传统的神经元检测方法针对这些复杂的功能域进行治疗发现一直具有挑战性。在这里，我们回顾神经元筛选技术和细胞模型系统的进展，这些技术和系统能够对神经元功能进行表型筛选，作为新型中枢神经系统药物发现方法的基础。
