Meurs Kathryn M
Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, 1060 William Moore Road, Raleigh, NC 27601, USA.
Vet Clin North Am Small Anim Pract. 2017 Sep;47(5):1103-1111. doi: 10.1016/j.cvsm.2017.04.007. Epub 2017 Jun 21.
Arrhythmogenic right ventricular cardiomyopathy is an inheritable form of myocardial disease characterized most commonly by ventricular tachycardias, syncope, and sometimes systolic dysfunction and heart failure. A genetic mutation in the striatin gene has been identified in many affected dogs. Dogs with only one copy of the mutation (heterozygous) have a variable prognosis, with many dogs remaining asymptomatic or being successfully managed on antiarrhythmic drugs for years. Dogs that are homozygous for the mutation seem to have a worse prognosis.
致心律失常性右室心肌病是一种遗传性心肌疾病，最常见的特征是室性心动过速、晕厥，有时还会出现收缩功能障碍和心力衰竭。在许多患病犬中已发现striatin基因发生了基因突变。只有一个突变拷贝（杂合子）的犬预后不一，许多犬无症状或通过抗心律失常药物成功治疗多年。该突变的纯合子犬预后似乎更差。
