Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA.
J Vet Intern Med. 2023 Sep-Oct;37(5):1667-1678. doi: 10.1111/jvim.16830. Epub 2023 Aug 14.
Holter electrocardiographic monitoring is a cornerstone of diagnostic testing for arrhythmogenic cardiomyopathy (ACM) in Boxer dogs, but physical activity during monitoring is not controlled. In humans, exercise testing (ExT) can identify latent tachyarrhythmias associated with cardiomyopathy, and exercise increases serum cardiac troponin-I concentrations ([hs-cTnI]). These effects have not yet been investigated in Boxer dogs.
HYPOTHESIS/OBJECTIVES: Subjecting Boxer dogs to brief, moderate-intensity ExT can identify changes in Holter recordings and [hs-cTnI] compared to baseline results.
Thirty overtly healthy, client-owned Boxer dogs.
Prospective interventional study. Dogs underwent baseline diagnostic testing including 24-hour Holter monitoring and [hs-cTnI], followed by brief ExT (accompanied, brisk stair-climbing and -descending for <5 minutes).
Eleven dogs (37%) had >100 premature ventricular complexes (PVCs)/24 hours at baseline (3), ExT (3), or both (5). After ExT, these dogs had more PVCs/24 hours and greater increases in [hs-cTnI] compared to those with ≤100 PVCs/24 hours. Dogs with the striatin mutation had more PVCs/24 hours and a greater increase in [hs-cTnI] after ExT than did dogs without the striatin mutation.
Exercise testing may improve the binary classification of Boxer dogs with or without ACM by increasing the number of PVCs and [hs-cTnI] in affected dogs to a greater degree than in unaffected dogs. This effect also is associated with presence or absence of the striatin mutation. Exercise should be a controlled variable when screening Boxer dogs for ACM.
动态心电图监测是 Boxer 犬致心律失常性心肌病（ACM）诊断测试的基石，但监测期间的身体活动不受控制。在人类中，运动试验（ExT）可以识别与心肌病相关的潜在心动过速性心律失常，并且运动增加血清心肌肌钙蛋白 I 浓度 ([hs-cTnI])。这些影响尚未在 Boxer 犬中进行研究。
假设/目的：让 Boxer 犬进行短暂的、中等强度的 ExT 可以与基线结果相比，识别 Holter 记录和 [hs-cTnI] 的变化。
30 只明显健康的、有主人的 Boxer 犬。
前瞻性干预研究。犬接受基线诊断测试，包括 24 小时 Holter 监测和 [hs-cTnI]，然后进行短暂的 ExT（<5 分钟的陪同下快速上下楼梯）。
11 只犬（37%）在基线（3 只）、ExT（3 只）或两者（5 只）时的室性期前收缩（PVCs）/24 小时>100 次。在 ExT 后，这些犬的 PVCs/24 小时更多，[hs-cTnI] 增加更多，与 PVCs/24 小时≤100 次的犬相比。与没有 striatin 突变的犬相比，具有 striatin 突变的犬的 PVCs/24 小时更多，且 [hs-cTnI] 增加更多。
运动试验可通过增加受影响犬的 PVCs 和 [hs-cTnI] 数量，使其比未受影响犬更显著，从而提高 Boxer 犬有无 ACM 的二分类。这种效果也与 striatin 突变的存在与否有关。在对 Boxer 犬进行 ACM 筛查时，运动应作为一个受控变量。
