Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary; MTA-SE Lendület Neurobiochemistry Research Group, Hungary.
Neurochem Int. 2018 Jul;117:49-54. doi: 10.1016/j.neuint.2017.06.010. Epub 2017 Jun 21.
Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere.
目前关于线粒体通透性转换（mPT）孔由什么组成的理论模型，暗示了 ATP 合酶复合物的 c 亚基环。然而，最近的两项研究，一项是关于原子模拟，另一项是破坏所有编码 c 亚基的基因，都否定了这些模型。因此，孔的结构元素仍然未知。本简短综述的目的是：（i）简要回顾最新发现，（ii）作为关于 mPT 具体内容的更全面综述的索引，（iii）在结合生物能量学研究 mPT 时重申潜在的陷阱，最重要的是（iv）建议那些正在寻找 mPT 孔身份的人也到其他地方寻找。
