法国2015年急性ST段抬高型和非ST段抬高型心肌梗死注册研究（FAST-MI 2015）。设计与基线数据。
French Registry on Acute ST-elevation and non-ST-elevation Myocardial Infarction 2015 (FAST-MI 2015). Design and baseline data.
作者信息
Belle Loïc, Cayla Guillaume, Cottin Yves, Coste Pierre, Khalife Khalife, Labèque Jean-Noël, Farah Bruno, Perret Thibaut, Goldstein Patrick, Gueugniaud Pierre-Yves, Braun François, Gauthier Jacques, Gilard Martine, Le Heuzey Jean-Yves, Naccache Nicolas, Drouet Elodie, Bataille Vincent, Ferrières Jean, Puymirat Etienne, Schiele François, Simon Tabassome, Danchin Nicolas
机构信息
Department of cardiology, centre hospitalier Annecy-Genevois, Annecy, France, Collège national des cardiologues des hôpitaux, Paris, France.
Department of Cardiology, centre hospitalier universitaire de Nîmes, université de Montpellier, Montpellier, France.
出版信息
Arch Cardiovasc Dis. 2017 Jun-Jul;110(6-7):366-378. doi: 10.1016/j.acvd.2017.05.001. Epub 2017 Jun 21.
BACKGROUND
The FAST-MI programme, consisting of 1-month surveys of patients admitted to hospital for acute myocardial infarction (AMI) in France, has run since 2005.
AIM
To gather data on the characteristics, management and outcomes of patients hospitalized for AMI at the end of 2015 in France and to provide comparisons with the previous surveys.
METHODS
Consecutive adults with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment-elevation myocardial infarction (NSTEMI) with symptom onset≤48hours were included over a 1-month period, with a possible extension of recruitment for 1 additional month. Patients with AMI following cardiovascular procedures were excluded. In all, 204 centres participated in the survey (114 community hospitals, 40 academic, 48 private clinics, 2 army hospitals), representing 78% of French centres managing AMI patients. Inclusion started from 5 October 2015. Data were collected on-site from source files by external research technicians, using an electronic case record form with automatic quality checks. Centralized biology was organized in voluntary centres to collect RNA and DNA samples, serum and stools. Long-term follow-up was organized centrally with interrogation of municipal registry offices, physicians and by direct contact with the patients or their families.
RESULTS
A total of 5291 patients were included over the entire recruitment period, with 3813 included during the first month (STEMI: 49%, NSTEMI: 51%). Mean age was 66±14 years, 29% were≥75 years of age, 28% were women; 80% presented with typical chest pain. In STEMI patients, 6% received intravenous fibrinolysis and 71% underwent primary PCI. The hospital death rate was 2.7% (STEMI: 2.8%, NSTEMI: 2.5%).
CONCLUSIONS
Recruitment was in line with expectations and the first data show that management has continued to evolve since the 2010 survey, with continued improvement in hospital outcomes.
背景
自2005年起开展的FAST-MI项目，对法国因急性心肌梗死（AMI）入院的患者进行为期1个月的调查。
目的
收集2015年末法国因AMI住院患者的特征、治疗及预后数据，并与之前的调查进行比较。
方法
在1个月期间纳入症状发作≤48小时的连续性ST段抬高型心肌梗死（STEMI）或非ST段抬高型心肌梗死（NSTEMI）成年患者，招募期可能延长1个月。排除心血管手术后发生AMI的患者。共有204个中心参与了该调查（114家社区医院、40家学术机构、48家私立诊所、2家军队医院），占法国管理AMI患者中心的78%。纳入工作于2015年10月5日开始。外部研究技术人员使用带有自动质量检查功能的电子病例记录表格，从源文件中现场收集数据。在自愿参与的中心组织集中生物学检测，以收集RNA和DNA样本、血清及粪便。通过询问市政登记处、医生并直接联系患者或其家属，集中组织长期随访。
结果
在整个招募期间共纳入5291例患者，第一个月纳入3813例（STEMI：49%，NSTEMI：51%）。平均年龄为66±14岁，29%的患者年龄≥75岁，28%为女性；80%表现为典型胸痛。在STEMI患者中,6%接受静脉溶栓治疗，71%接受直接经皮冠状动脉介入治疗（PCI）。住院死亡率为2.7%（STEMI：2.8%，NSTEMI：2.5%）。
结论
招募情况符合预期，首批数据表明自2010年调查以来治疗方法持续演变，住院结局持续改善。
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