Tenedieva V D, Arestov O G, Mikrikova L V, Sirovskiĭ E B, Kadashev B A
Zh Vopr Neirokhir Im N N Burdenko. 1985 Jul-Aug(4):37-42.
Clinical and biochemical examination conducted in 40 patients with tumors of the sellar-diencephalic region before and after operation and in 8 healthy individuals revealed in the patients disorders of the function of the hypothalamus and alpha- and beta-cells of the pancreas in the presence of neurological and endocrine disorders. Radioimmunologic determination of insulin and glucagon in the blood disclosed activation of alpha- and beta-cells of the islets of Langerhans in patients with normal blood glucose content before surgery and inadequacy of the reaction of the pancreatic alpha- and beta-cells to the operation stress in patients with diminished or increased concentration of glucose in blood before surgery. Dysfunction of the hypothalamus and endocrine cells of the pancreas in tumors of the sellar-diencephalic region gives grounds for applying postoperative corrective therapy including preparations of insulin and glucagon in patients with progressive signs of a brain lesion.
对40例鞍区 - 间脑区肿瘤患者手术前后及8名健康个体进行的临床和生化检查显示，患者存在下丘脑及胰腺α细胞和β细胞功能紊乱，并伴有神经和内分泌紊乱。对血液中胰岛素和胰高血糖素的放射免疫测定表明，术前血糖含量正常的患者，其胰岛α细胞和β细胞被激活；而术前血糖浓度降低或升高的患者，胰腺α细胞和β细胞对手术应激的反应不足。鞍区 - 间脑区肿瘤患者下丘脑和胰腺内分泌细胞功能障碍，为对有脑损伤进展迹象的患者应用包括胰岛素和胰高血糖素制剂在内的术后纠正治疗提供了依据。
