Wang X B, Hong L C, Wei Y Z, Fu X, Bao X Q, Zhang J, Hu G, Wu S H, Cheng J Q
School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
School of Public Health, Southern Medical University, Guangzhou 510515, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jun 10;38(6):784-788. doi: 10.3760/cma.j.issn.0254-6450.2017.06.019.
To analyze the epidemiological features, spectrum and case fatality of malignant tumor patients in Shenzhen city, to provide evidence for the development of prevention and treatment strategies on malignant tumor in Shenzhen. All the hospitalized malignant tumor patients including deaths, were monitored from 1995 to 2014 in Shenzhen, and data was analyzed by SPSS 20.0 software. There were 160 988 inpatients of malignant tumors between 1995 and 2014 in Shenzhen. The top three hospitalized tumors were lung (13.64), liver (11.13) and breast (7.86) cancers. Numbers of the malignant tumor inpatients had been rapidly increasing during the past 20 years, 12.3 times in 2014 higher than in 1995. The total number of deaths due to malignant tumors was 19 460. Deaths of the top three malignant tumors were lung (24.40), liver (19.84) and colorectal (8.63) cancers and the number of deaths was increasing, 12.5 times higher in 2014 than in 1995. The overall case fatality rate was 12.09. The annual percent change (APC) of malignant tumors case fatality rate was 9.7(95: 2.0-18.0), during 1995-2003, with an increasing trend (=2.72, <0.05). The APC of case fatality rate during 2003-2014 was -3.4(95: -7.6-1.1), but the decreasing trend (=-1.63, >0.05) was not statistically significant. The top three major malignant tumors related to case fatality rate were lung cancer (21.62), liver cancer (21.39), and esophageal cancer (16.50). The case fatality rates of leukemia and liver cancer had decreased during the past 20 years. The case fatality rates of cancers in lung, esophagus, stomach, breast, colorectal and nasopharyngeal, had all increased. The number of male patients was significantly exceeding the females ((2)=41.691, <0.01), with sex ratio as 1.65∶1. From age 35 and on, the number of deaths due to malignant tumors increased significantly, with the peak after 60 years of age. The number of malignant tumor inpatients had an annual increase as well as the case fatality rate. Cancers in lung, liver appeared the leading causes of death among the malignant tumor patients, with elderly in particular. Strategies related to the prevention and treatment of cancers in lung, liver should be strengthened.
分析深圳市恶性肿瘤患者的流行病学特征、疾病谱及病死率,为制定深圳市恶性肿瘤防治策略提供依据。对1995年至2014年深圳市所有住院恶性肿瘤患者(包括死亡病例)进行监测,并用SPSS 20.0软件进行数据分析。1995年至2014年深圳市有160988例恶性肿瘤住院患者。住院人数居前三位的肿瘤分别是肺癌(13.64)、肝癌(11.13)和乳腺癌(7.86)。过去20年恶性肿瘤住院人数迅速增加,2014年是1995年的12.3倍。恶性肿瘤死亡总数为19460例。死亡人数居前三位的恶性肿瘤分别是肺癌(24.40)、肝癌(19.84)和结直肠癌(8.63),且死亡人数呈上升趋势,2014年是1995年的12.5倍。总体病死率为12.09。1995 - 2003年恶性肿瘤病死率的年度变化百分比(APC)为9.7(95%CI:2.0 - 18.0),呈上升趋势(χ² = 2.72,P < 0.05)。2003 - 2014年病死率的APC为 - 3.4(95%CI: - 7.6 - 1.1),但下降趋势(χ² = - 1.63,P > 0.05)无统计学意义。与病死率相关的前三位主要恶性肿瘤是肺癌(21.62)、肝癌(21.39)和食管癌(16.50)。白血病和肝癌的病死率在过去20年有所下降。肺癌、食管癌、胃癌、乳腺癌、结直肠癌和鼻咽癌的病死率均有所上升。男性患者数量显著超过女性(χ² = 41.691,P < 0.01),男女比例为1.65∶1。35岁及以上,恶性肿瘤死亡人数显著增加,60岁以后达到峰值。恶性肿瘤住院人数和病死率均呈逐年上升趋势。肺癌、肝癌是恶性肿瘤患者尤其是老年患者的主要死亡原因。应加强肺癌、肝癌的防治策略。