Li Z, Fu X Y, Fang X B, Li J, Chen T, Qiu L M, Cai J, Wang W L, Pan Z Q, Zhang Y, Zhou J L
1the People's Hospital of QIAN East-southern state of Guizhou Province, Guizhou Kaili 556000, China.
Zhonghua Yi Xue Za Zhi. 2017 Jun 27;97(24):1883-1887. doi: 10.3760/cma.j.issn.0376-2491.2017.24.009.
To investigate the clinical efficacy of atomization inhalation combined with oral administration of oseltamivir in treatment of human infection with H7N9 avian influenza. To analyze the clinical data of 4 patients hospitalized from Mar 6th 2017 to Apr 12th 2017 with avian influenza(H7N9) infection treated by conventional therapy(oseltamivir, 150 mg, po, Bid) plus with oseltamivir inhalation(75 mg dissolved in 20 ml N. S, Bid) and administered with antibacterial treatment, blood purification and immunomodulators. Undergoing these comprehensive therapies, Bronchial lavage fluid and pharynx of 1 case was negative for H7N9 RNA after 24 h, 2 cases negative for H7N9 after 3 d and 1 case negative for H7N9 RNA after 4 d. All patients were cured and discharged without any complications. Aseltamivir inhalation combined with oral treatment can significantly shorten the time of virus nucleic acid turning negative, improve the efficacy of anti avian influenza virus H7N9, and increase the cure rate of avian influenza H7N9 infection patients.
探讨雾化吸入联合口服奥司他韦治疗人感染H7N9禽流感的临床疗效。分析2017年3月6日至2017年4月12日收治的4例禽流感（H7N9）感染患者的临床资料，患者接受常规治疗（奥司他韦，150 mg，口服，每日2次）加奥司他韦雾化吸入（75 mg溶于20 ml生理盐水中，每日2次），并给予抗菌治疗、血液净化及免疫调节剂。经过这些综合治疗，1例患者支气管灌洗液及咽拭子在24小时后H7N9 RNA检测为阴性，2例在3天后H7N9检测为阴性，1例在4天后H7N9 RNA检测为阴性。所有患者均治愈出院，无任何并发症。奥司他韦雾化吸入联合口服治疗可显著缩短病毒核酸转阴时间，提高抗H7N9禽流感病毒疗效，提高H7N9禽流感感染患者治愈率。
