Abe Yoshiyuki, Tada Kurisu, Yamaji Ken, Takasaki Yoshinari, Tamura Naoto
a Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
b Juntendo University Koshigaya Hospital , Saitama , Japan.
Mod Rheumatol. 2018 Mar;28(2):308-312. doi: 10.1080/14397595.2017.1337265. Epub 2017 Jun 26.
To determine mortality and its predictive factors in Japanese patients with polyarteritis nodosa (PAN).
This retrospective single-center study determined the mortality of 18 patients with PAN who were admitted to Juntendo University Hospital from 1994 to 2016. The variables at baseline, including patient demographics, clinical characteristics, and treatment, were analyzed for their association with mortality.
The median age of onset was 57.0 years. The 1-year survival rate was 100% (16/16) and the 5-year survival rate was 80.0% (8/10). The relationship between mortality, as defined by the survival rate and each variable was evaluated by Cox univariate analysis. A higher 2009 five-factor score (FFS) was associated with increased mortality, with a hazard ratio of 2.34 (p = .04). Analysis of the secondary outcome of relapse-free survival time revealed an association with rapid progressive renal failure, Birmingham Vasculitis Activity Score (BVAS), the 1996 FFS, and the 2009 FFS, with hazard ratios of 7.28 (p = .048), 1.26 (p = .02), 2.32 (p = .03), and 1.82 (p = .04), respectively.
We investigated mortality, relapse-free survival, and their predictive factors in Japanese patients with PAN. The BVAS and the 1996 FFS at diagnosis may be prognostic factors for relapse-free survival, and the 2009 FFS at diagnosis may be a prognostic factor for both mortality and relapse-free survival.
确定日本结节性多动脉炎（PAN）患者的死亡率及其预测因素。
这项回顾性单中心研究确定了1994年至2016年期间入住顺天堂大学医院的18例PAN患者的死亡率。分析了包括患者人口统计学、临床特征和治疗在内的基线变量与死亡率的关联。
发病年龄中位数为57.0岁。1年生存率为100%（16/16），5年生存率为80.0%（8/10）。通过Cox单因素分析评估生存率定义的死亡率与每个变量之间的关系。2009年较高的五因素评分（FFS）与死亡率增加相关，风险比为2.34（p = 0.04）。对无复发生存时间的次要结局分析显示，其与快速进行性肾衰竭、伯明翰血管炎活动评分（BVAS）、1996年FFS和2009年FFS相关，风险比分别为7.28（p = 0.048）、1.26（p = 0.02）、2.32（p = 0.03）和1.82（p = 0.04）。
我们调查了日本PAN患者的死亡率、无复发生存率及其预测因素。诊断时的BVAS和1996年FFS可能是无复发生存的预后因素，诊断时的2009年FFS可能是死亡率和无复发生存的预后因素。
