Kularatna Sanjeewa, Chen Gang, Byrnes Josh, Scuffham Paul A
Centre for Applied Health Economics, School of Medicine, Griffith University, Brisbane, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia.
Centre for Health Economics, Monash Business School, Monash University.
Value Health Reg Issues. 2017 May;12:20-23. doi: 10.1016/j.vhri.2017.01.001. Epub 2017 Apr 26.
Quality-adjusted life-years are the common outcome measure in contemporary economic evaluations in health care. Due to the limitations of the sensitivity of the EQ-5D-3L in specific disease conditions, the EuroQoL group has developed a new EQ-5D-5L classification system with 3,125 health states. This study estimated the Sri Lankan value set for the EQ-5D-5L using a crosswalk methodology.
The EuroQoL group had developed a crosswalk methods to obtain interim value set for the EQ-5D-5L health states using available EQ-5D-3L values. This was achieved by mapping EQ-5D-3L and EQ-5D-5L ratings through cross tabulations by each dimension level. Using above official EuroQoL crosswalk probabilities, an interim value set for the Sri Lankan EQ-5D-5L health states were generated based upon the Sri Lankan EQ-5D-3L value set (which was estimated using time trade-off method: n= 780). Comparison were conducted between the Sri Lankan EQ-5D-5L values and other countries.
The Sri Lankan EQ-5D-5L recorded utility value of -0.73 for the worst health state and 0.85 for a best possible utility for a health state other than the full health. The UK (mean= 0.4) and Japanese (mean = 0.45) EQ-5D-5L mean utility values were higher than the Sri Lankan values (mean = 0.07). However, Thailand median values (0.21) were closer to the Sri Lankan median values (0.14) than the UK (0.41) or Japan (0.45).
This study produced the Sri Lankan EQ-5D-5L interim value set using crosswalk methods. Currently, this is the only EQ-5D-5L value set available for the South Asian region.
质量调整生命年是当代医疗保健经济评估中常用的结果指标。由于EQ-5D-3L在特定疾病状况下敏感性存在局限性，欧洲生活质量小组开发了一种新的EQ-5D-5L分类系统，包含3125种健康状态。本研究采用交叉法估计了斯里兰卡的EQ-5D-5L价值集。
欧洲生活质量小组开发了一种交叉法，利用现有的EQ-5D-3L值来获取EQ-5D-5L健康状态的临时价值集。这是通过按每个维度水平进行交叉列表来映射EQ-5D-3L和EQ-5D-5L评级实现的。利用上述欧洲生活质量小组官方交叉概率，基于斯里兰卡EQ-5D-3L价值集（采用时间权衡法估计：n = 780）生成了斯里兰卡EQ-5D-5L健康状态的临时价值集。对斯里兰卡EQ-5D-5L值与其他国家的值进行了比较。
斯里兰卡EQ-5D-5L记录的最差健康状态效用值为-0.73，除完全健康外的最佳健康状态效用值为0.85。英国（均值 = 0.4）和日本（均值 = 0.45）的EQ-5D-5L平均效用值高于斯里兰卡的值（均值 = 0.07）。然而，泰国的中位数（0.21）比英国（0.41）或日本（0.45）的中位数更接近斯里兰卡的中位数（0.14）。
本研究采用交叉法生成了斯里兰卡EQ-5D-5L临时价值集。目前，这是南亚地区唯一可用的EQ-5D-5L价值集。
