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老年动脉瘤性疾病择期主动脉半弓重建的结果

Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly.

作者信息

Kilic Arman, Arnaoutakis George J, Bavaria Joseph E, Sultan Ibrahim, Desai Nimesh D, Vallabhajosyula Prashanth, Williams Matthew L, Milewski Rita K, Szeto Wilson Y

机构信息

Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

出版信息

Ann Thorac Surg. 2017 Nov;104(5):1522-1530. doi: 10.1016/j.athoracsur.2017.03.067. Epub 2017 Jun 23.

Abstract

BACKGROUND

This study evaluated outcomes of elective aortic hemiarch reconstruction for aneurysmal disease in the elderly.

METHODS

Patients undergoing elective aortic hemiarch reconstruction for aneurysmal disease at a single institution between 2009 and 2014 were retrospectively reviewed. Patients were stratified into nonelderly (aged less than 75 years) versus elderly (aged 75 years or more). Outcomes included operative mortality and morbidity.

RESULTS

In all, 629 patients (95 elderly; 15%) were included. Elderly patients had a greater comorbidity burden. Concomitant aortic valve replacement and coronary artery bypass were performed more frequently whereas root replacement was performed less frequently in the elderly. The overall stroke rate was 1.8% and was higher among the elderly (4.2% versus 1.3%, p = 0.05), although this difference no longer persisted after risk adjustment (odds ratio 2.54, p = 0.17). Median length of intensive care unit and hospital stay were longer in the elderly (64 versus 41 hours and 9 versus 7 days, respectively; each p < 0.001). Unadjusted and risk-adjusted operative mortality were similar (2.1% elderly versus 0.9% nonelderly, p = 0.32). Elderly patients were less frequently discharged to home (65% versus 95%, p < 0.001). Propensity matched analysis confirmed these findings. Moderate hypothermic circulatory arrest with antegrade cerebral perfusion was a safe strategy for the elderly patients, with stroke and operative mortality rates of 0% each.

CONCLUSIONS

Although elderly patients have a more prolonged recovery after elective aortic hemiarch reconstruction for aneurysmal disease, outcomes are acceptable with low operative mortality and with the majority being discharged home. Moderate hypothermic circulatory arrest with antegrade cerebral perfusion is a safe strategy for this cohort. Advanced age alone should not be viewed as a contraindication in these cases.

摘要

背景

本研究评估了老年患者因动脉瘤性疾病接受选择性主动脉半弓重建术的疗效。

方法

对2009年至2014年在单一机构因动脉瘤性疾病接受选择性主动脉半弓重建术的患者进行回顾性分析。患者被分为非老年组(年龄小于75岁)和老年组(年龄75岁及以上)。观察指标包括手术死亡率和发病率。

结果

共纳入629例患者(95例老年患者,占15%)。老年患者合并症负担更重。老年患者中,同期行主动脉瓣置换术和冠状动脉旁路移植术更为频繁,而行根部置换术则较少。总体卒中发生率为1.8%,老年患者中更高(4.2%对1.3%,p = 0.05),尽管风险调整后这种差异不再存在(优势比2.54,p = 0.17)。老年患者重症监护病房住院时间和住院时间中位数更长(分别为64小时对41小时和9天对7天;p均<0.001)。未调整和风险调整后的手术死亡率相似(老年患者为2.1%,非老年患者为0.9%,p = 0.32)。老年患者出院回家的比例较低(65%对95%,p < 0.001)。倾向评分匹配分析证实了这些结果。中度低温体外循环停循环并顺行性脑灌注对老年患者是一种安全的策略,卒中率和手术死亡率均为0%。

结论

尽管老年患者因动脉瘤性疾病接受选择性主动脉半弓重建术后恢复时间更长,但手术死亡率低,大多数患者出院回家,疗效尚可。中度低温体外循环停循环并顺行性脑灌注对该人群是一种安全的策略。在这些病例中,不应仅将高龄视为禁忌证。

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