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以三唑为桥连单元通过点击化学合成胆汁酸树枝状大分子及其抗癌活性

Synthesis and anticancer activity of bile acid dendrimers with triazole as bridging unit through click chemistry.

作者信息

Anandkumar Devaraj, Rajakumar Perumal

机构信息

Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600025, TamilNadu, India.

Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600025, TamilNadu, India.

出版信息

Steroids. 2017 Sep;125:37-46. doi: 10.1016/j.steroids.2017.06.007. Epub 2017 Jun 23.

Abstract

Triazole-based novel dendrimers with bile acid surface groups have been synthesized through click chemistry by divergent approach and characterized by spectral data. All the dendrimers exhibit excellent anticancer activity. Higher-generation dendrimers exhibit better anticancer activity than the lower-generation dendrimers.

摘要

通过发散法利用点击化学合成了具有胆汁酸表面基团的基于三唑的新型树枝状大分子,并通过光谱数据对其进行了表征。所有树枝状大分子均表现出优异的抗癌活性。高代树枝状大分子比低代树枝状大分子表现出更好的抗癌活性。

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