• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

树枝状大分子：生物活性分子递送系统的惊人平台。

Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems.

作者信息

Sandoval-Yañez Claudia, Castro Rodriguez Cristian

机构信息

Institute of Applied Chemical Sciences, Faculty of Engineering, Universidad Autonoma de Chile, El Llano Subercaseaux 2801, San Miguel 8910060, Santiago-Chile, Chile.

Departamento de Química, Facultad de Ciencias, Universidad de Tarapacá, Avenida General Velásquez 1775, Arica-Chile 1000007, Chile.

出版信息

Materials (Basel). 2020 Jan 24;13(3):570. doi: 10.3390/ma13030570.

DOI:10.3390/ma13030570
PMID:31991703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7040653/
Abstract

Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

摘要

如今，树枝状大分子是应用于药物递送系统的主要纳米颗粒。树枝状大分子的物理化学特性及其多样的结构修饰使其成为生物活性分子运输平台的理想选择。基于树枝状大分子的纳米制剂可提高低溶解度药物到达靶组织的能力、药物生物利用度以及实现控释。本综述描述了基于树枝状大分子的生物活性分子运输的后一种方法。综述重点关注与生物活性分子共轭的树枝状大分子所采用的最新治疗策略。本文还简要回顾了癌症和心血管疾病治疗的最新研究以及该领域的未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/251d06edc811/materials-13-00570-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/2bd192da0c5b/materials-13-00570-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/7edc60a880d4/materials-13-00570-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/1ac3eff17460/materials-13-00570-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/7be7b0c46120/materials-13-00570-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/c5820dc4f837/materials-13-00570-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/63de2ebd4999/materials-13-00570-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/70dbccd5eb2b/materials-13-00570-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/06e876075d87/materials-13-00570-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/061e8f30757e/materials-13-00570-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/6983c9efeb77/materials-13-00570-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/d1e6d3a63001/materials-13-00570-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/251d06edc811/materials-13-00570-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/2bd192da0c5b/materials-13-00570-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/7edc60a880d4/materials-13-00570-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/1ac3eff17460/materials-13-00570-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/7be7b0c46120/materials-13-00570-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/c5820dc4f837/materials-13-00570-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/63de2ebd4999/materials-13-00570-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/70dbccd5eb2b/materials-13-00570-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/06e876075d87/materials-13-00570-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/061e8f30757e/materials-13-00570-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/6983c9efeb77/materials-13-00570-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/d1e6d3a63001/materials-13-00570-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/7040653/251d06edc811/materials-13-00570-sch008.jpg

相似文献

1
Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems.树枝状大分子：生物活性分子递送系统的惊人平台。
Materials (Basel). 2020 Jan 24;13(3):570. doi: 10.3390/ma13030570.
2
Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review.肽和糖缀合树枝状聚合物用于靶向药物传递：简要综述。
Interface Focus. 2012 Jun 6;2(3):307-24. doi: 10.1098/rsfs.2012.0009. Epub 2012 Mar 21.
3
Dendrimers for Drug Delivery.树枝状聚合物用于药物递送。
Molecules. 2018 Apr 18;23(4):938. doi: 10.3390/molecules23040938.
4
Dendrimers as efficient nanocarriers for the protection and delivery of bioactive phytochemicals.树状高分子作为有效的纳米载体保护和传递生物活性植物化学物质。
Adv Colloid Interface Sci. 2020 Apr;278:102125. doi: 10.1016/j.cis.2020.102125. Epub 2020 Feb 19.
5
Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules.树枝状聚合物对疏水性药物分子溶解度的影响
Front Pharmacol. 2017 May 16;8:261. doi: 10.3389/fphar.2017.00261. eCollection 2017.
6
Application of Dendrimers in Anticancer Diagnostics and Therapy.树状高分子在癌症诊断与治疗中的应用。
Molecules. 2022 May 18;27(10):3237. doi: 10.3390/molecules27103237.
7
Dendrimers in oral drug delivery application: current explorations, toxicity issues and strategies for improvement.树枝状大分子在口服药物递送中的应用：当前研究、毒性问题及改进策略
Curr Pharm Des. 2015;21(19):2629-42. doi: 10.2174/1381612821666150416102058.
8
Polymeric Dendrimers as Nanocarrier Vectors for Neurotheranostics.作为神经治疗诊断纳米载体的聚合物树枝状大分子
Small. 2022 Nov;18(45):e2203629. doi: 10.1002/smll.202203629. Epub 2022 Sep 9.
9
Application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability.树枝状聚合物-药物络合在提高药物溶解度和生物利用度方面的应用。
Expert Opin Drug Metab Toxicol. 2008 Aug;4(8):1035-52. doi: 10.1517/17425255.4.8.1035.
10
Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies.多聚酰胺-胺树枝状聚合物提高小分子溶解度和其他特性的研究：来自实验和计算研究的见解。 用于实现小分子的高溶解性和其他所需特性的多聚酰胺-胺树状聚合物：基于实验和计算研究的见解。
Molecules. 2018 Jun 12;23(6):1419. doi: 10.3390/molecules23061419.

引用本文的文献

1
Theoretical and Experimental Analyses of the Interfacial Mechanism of Dendrimer-Doxorubicin Complexes Formation.树状大分子-阿霉素复合物形成的界面机制的理论与实验分析。
Mol Pharm. 2024 Nov 4;21(11):5892-5904. doi: 10.1021/acs.molpharmaceut.4c00941. Epub 2024 Oct 22.
2
Strategies for transportation of peptides across the skin for treatment of multiple diseases.肽经皮转运用于多种疾病治疗的策略。
Ther Deliv. 2025 Jan;16(1):63-86. doi: 10.1080/20415990.2024.2411943. Epub 2024 Oct 16.
3
A Comprehensive Review on Repurposing the Nanocarriers for the Treatment of Parkinson's Disease: An Updated Patent and Clinical Trials.

本文引用的文献

1
A degradable hydrogel formed by dendrimer-encapsulated platinum nanoparticles and oxidized dextran for repeated photothermal cancer therapy.一种由树枝状聚合物包裹的铂纳米颗粒和氧化葡聚糖形成的可降解水凝胶，用于重复光热癌症治疗。
J Mater Chem B. 2018 Apr 28;6(16):2474-2480. doi: 10.1039/c8tb00091c. Epub 2018 Apr 12.
2
Development of Mesoporous Silica Nanoparticles of Tunable Pore Diameter for Superior Gemcitabine Drug Delivery in Pancreatic Cancer Cells.可调孔径介孔硅纳米粒子的开发用于胰腺癌细胞中吉西他滨的高效药物传递。
J Nanosci Nanotechnol. 2020 May 1;20(5):3084-3096. doi: 10.1166/jnn.2020.17381.
3
pH-Responsive Lipid-Dendrimer Hybrid Nanoparticles: An Approach To Target and Eliminate Intracellular Pathogens.
纳米载体用于治疗帕金森病的再利用综合综述：最新专利与临床试验
CNS Neurol Disord Drug Targets. 2025;24(3):181-195. doi: 10.2174/0118715273323074241001071645.
4
Biocompatible Glycopolymer-PLA Amphiphilic Hybrid Block Copolymers with Unique Self-Assembly, Uptake, and Degradation Properties.具有独特自组装、摄取和降解性能的生物相容糖基聚合物-PLA 两亲性杂化嵌段共聚物。
Biomacromolecules. 2024 Oct 14;25(10):6681-6692. doi: 10.1021/acs.biomac.4c00885. Epub 2024 Sep 14.
5
Dendrimers-Novel Therapeutic Approaches for Alzheimer's Disease.树枝状大分子——治疗阿尔茨海默病的新方法
Biomedicines. 2024 Aug 20;12(8):1899. doi: 10.3390/biomedicines12081899.
6
Molecular Ballet: Investigating the Complex Interaction between Self-Assembling Dendrimers and Human Serum Albumin via Computational and Experimental Methods.分子之舞：通过计算和实验方法研究自组装树枝状大分子与人类血清白蛋白之间的复杂相互作用
Pharmaceutics. 2024 Apr 12;16(4):533. doi: 10.3390/pharmaceutics16040533.
7
Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria.互补的超分子药物配合物在完善多药耐药菌的多药治疗中的作用。
Front Immunol. 2024 Feb 13;15:1352483. doi: 10.3389/fimmu.2024.1352483. eCollection 2024.
8
New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment.非小细胞肺癌纳米系统的新见解：诊断与治疗
RSC Adv. 2023 Jun 28;13(28):19540-19564. doi: 10.1039/d3ra03099g. eCollection 2023 Jun 22.
9
Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC).纳米介导的策略用于针对和治疗非小细胞肺癌（NSCLC）。
Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov;396(11):2769-2792. doi: 10.1007/s00210-023-02522-5. Epub 2023 May 23.
10
Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy.纳米颗粒已从肺癌治疗的临床前研究进入临床试验阶段。
Cancer Nanotechnol. 2023;14(1):28. doi: 10.1186/s12645-023-00174-x. Epub 2023 Mar 28.
pH 响应性脂质-树状聚合物杂化纳米颗粒：一种靶向和消除细胞内病原体的方法。
Mol Pharm. 2019 Nov 4;16(11):4594-4609. doi: 10.1021/acs.molpharmaceut.9b00713. Epub 2019 Oct 16.
4
Synthesis of Stimuli-Responsive Heterofunctional Dendrimer by Passerini Multicomponent Reaction.通过Passerini多组分反应合成刺激响应性杂功能树枝状大分子。
ACS Omega. 2019 Apr 11;4(4):6660-6668. doi: 10.1021/acsomega.9b00384. eCollection 2019 Apr 30.
5
Poly(amidoamine) Dendrimer as a Respiratory Nanocarrier: Insights from Experiments and Molecular Dynamics Simulations.聚酰胺-胺树枝状聚合物作为呼吸纳米载体：实验和分子动力学模拟的见解。
Langmuir. 2019 Apr 16;35(15):5364-5371. doi: 10.1021/acs.langmuir.9b00434. Epub 2019 Mar 29.
6
Understanding Effects of PAMAM Dendrimer Size and Surface Chemistry on Serum Protein Binding with Discrete Molecular Dynamics Simulations.通过离散分子动力学模拟了解聚酰胺-胺型树枝状大分子的大小和表面化学对血清蛋白结合的影响。
ACS Sustain Chem Eng. 2018 Sep 4;6(9):11704-11715. doi: 10.1021/acssuschemeng.8b01959. Epub 2018 Jul 31.
7
In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by "click" chemistry.通过“点击”化学修饰的 PAMAM 树枝状大分子的体外活性对克氏锥虫滋养体形式的甾体树突状聚合物。
Bioorg Chem. 2019 May;86:452-458. doi: 10.1016/j.bioorg.2019.01.056. Epub 2019 Jan 28.
8
A novel RGDyC/PEG co-modified PAMAM dendrimer-loaded arsenic trioxide of glioma targeting delivery system.一种新型 RGDyC/PEG 共修饰的载三氧化二砷靶向神经胶质瘤的 PAMAM 树枝状大分子给药系统。
Int J Nanomedicine. 2018 Oct 2;13:5937-5952. doi: 10.2147/IJN.S175418. eCollection 2018.
9
Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos.钌（II）/氨基酸/双膦配合物对瑞士小鼠和斑马鱼胚胎的急性毒性作用。
Biomed Pharmacother. 2018 Nov;107:1082-1092. doi: 10.1016/j.biopha.2018.08.051. Epub 2018 Aug 25.
10
Effect of pH on Size and Internal Structure of Poly(propylene imine) Dendrimers: A Molecular Dynamics Simulation Study.pH 值对聚（丙稀亚胺）树枝状大分子粒径和内部结构的影响：分子动力学模拟研究。
J Phys Chem B. 2018 Oct 4;122(39):9250-9263. doi: 10.1021/acs.jpcb.8b04653. Epub 2018 Sep 25.