疾病或储存相关的结构修饰不太可能解释 HDL 对巨噬细胞的促炎作用。
Disease- or Storage-Associated Structural Modifications Are Unlikely to Explain HDL Pro-inflammatory Effects on Macrophages.
机构信息
Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, 6211 LK Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80539 Munich, Germany.
Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, 6211 LK Maastricht, the Netherlands.
出版信息
Cell Metab. 2017 Jul 5;26(1):4-5. doi: 10.1016/j.cmet.2017.05.017. Epub 2017 Jun 22.
Van der Vorst et al. underscore the relevance of HDL quality control, considering HDL source and processing, but argue that disease- or storage-associated structural modifications of HDL cannot explain the observed pro-inflammatory effects on macrophages. Discrepancies between reported effects of HDL in macrophages are probably related to methodological differences.
范德沃特等人强调了 HDL 质量控制的相关性，考虑到了 HDL 的来源和加工，但他们认为，HDL 的疾病或储存相关结构修饰不能解释其对巨噬细胞的观察到的促炎作用。在巨噬细胞中报告的 HDL 作用之间的差异可能与方法学差异有关。
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