Rehman Jalilur, Akhtar Naveed, Asif Hafiz Muhammad, Sultana Sabira, Ahmad Mukhtiar
University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur, Pakistan / Department of Eastern Medicine, Qarshi University, Lahore, Pakistan.
University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur, Pakistan.
Pak J Pharm Sci. 2017 Mar;30(2):507-511.
Liver diseases are the most common ailment all over the world mostly caused by viruses, toxic chemicals, excessive intake of alcohol, high doses of paracetamol, carbon tetrachloride, chemotherapeutic agents and peroxides oil, etc. There is a great need to assess the scientific basis for the medicinal plants that are claimed to have hepatoprotective activity. We investigate the hepatoprotective effects of aqueous-ethanolic extract of Capparis decidua (Stems) against paracetamol induced liver injury in experimental animals. To observe the level of improvement, biochemical parameters such as SGPT, SGOT, ALP and Total bilirubin levels as well as histopathological changes in liver tissues were studied. Silymarin (50mg/kg, p.o.) was used as reference drug. The levels of the biochemical parameters were increased in rabbits which were intoxicate by paracetamol. Capparis decidua extract (750mg/kg, b.w.) treated rabbits showed maximum reduction of biochemical parameters in a significant (p<0.001) manner. Histopathological examination of the liver tissues of control and treated groups also confirmed the hepatoprotective activity. The phytochemical screening of the extracts revealed the presence of tannins, alkaloids, saponins and flavonoids. The results of the present study therefore suggest that the different doses of Capparis decidua possess significant hepatoprotective effect and this effect might be due to the presence of flavonoids and tannins.
肝脏疾病是全球最常见的疾病，主要由病毒、有毒化学物质、过量饮酒、高剂量对乙酰氨基酚、四氯化碳、化疗药物和过氧化物油等引起。迫切需要评估声称具有肝脏保护活性的药用植物的科学依据。我们研究了刺山柑（茎）水乙醇提取物对实验动物中对乙酰氨基酚诱导的肝损伤的肝脏保护作用。为了观察改善程度，研究了生化参数，如血清谷丙转氨酶（SGPT）、血清谷草转氨酶（SGOT）、碱性磷酸酶（ALP）和总胆红素水平，以及肝组织的组织病理学变化。水飞蓟宾（50mg/kg，口服）用作参比药物。对乙酰氨基酚中毒的兔子的生化参数水平升高。刺山柑提取物（750mg/kg，体重）处理的兔子的生化参数以显著（p<0.001）的方式最大程度降低。对照组和处理组肝组织的组织病理学检查也证实了肝脏保护活性。提取物的植物化学筛选显示存在单宁、生物碱、皂苷和类黄酮。因此，本研究结果表明，不同剂量的刺山柑具有显著的肝脏保护作用，这种作用可能归因于类黄酮和单宁的存在。
