Mandal S C, Saraswathi B, Kumar C K, Mohana Lakshmi S, Maiti B C
Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta - 700 032, India.
Phytother Res. 2000 Sep;14(6):457-9. doi: 10.1002/1099-1573(200009)14:6<457::aid-ptr610>3.0.co;2-8.
The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of Liv-52 a known hepatoprotective formulation.
对榕属植物糙叶榕（桑科）叶片的甲醇提取物进行了评估，通过给大鼠口服对乙酰氨基酚（750毫克/千克）诱导急性肝损伤，来研究其对大鼠的肝保护活性。口服剂量为400毫克/千克的提取物通过降低血清转氨酶（谷草转氨酶和谷丙转氨酶）、胆红素和碱性磷酸酶（ALP）水平，表现出显著的保护作用。这些生化观察结果得到了肝脏切片组织病理学检查的补充。提取物的活性也与已知的肝保护制剂利维52相当。
