Matsushita Takehiko, Tanaka Toshikazu
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan.
Clin Calcium. 2017;27(7):933-939.
Articular cartilage is an important structure contributing to shock absorption and joint lubrication. Aging and trauma cause loss of function of articular cartilage, resulting in osteoarthritis(OA). Chondrocyte, the only type of the cell that resides in the articular cartilage. Recent studies have revealed that aging-associated changes in chondrocytes are important causative factors of OA. This review describes various mechanism and factors involved in aging of articular cartilage and chondrocytes.
关节软骨是一种有助于减震和关节润滑的重要结构。衰老和创伤会导致关节软骨功能丧失，进而引发骨关节炎（OA）。软骨细胞是关节软骨中唯一存在的细胞类型。最近的研究表明，软骨细胞中与衰老相关的变化是骨关节炎的重要致病因素。这篇综述描述了关节软骨和软骨细胞衰老过程中涉及的各种机制和因素。
