Eisenburger R, Seibel K, Hampel H
Arzneimittelforschung. 1985;35(7):1076-9.
Etilefrine pivalate (K 30 052, Ep) and etilefrine (E) were compared in regard to their effects on the circulation of cats and dogs and in regard to their effects on isolated organs (papillary muscles, atria, vena cava caudalis) of guinea pigs and rabbits. The effects of Ep and E were qualitatively equal. Ep was less effective than E on isolated organs and after intravenous injection, it was however more effective after oral or intraduodenal application. This result is in line with the hypothesis that Ep is inactivated during the first-pass to a smaller extent than E and is split after absorption to E and pivalinic acid.
比较了匹伐依替福林（K 30 052，Ep）和依替福林（E）对猫和狗循环系统的影响，以及对豚鼠和兔子离体器官（乳头肌、心房、尾侧腔静脉）的影响。Ep和E的作用在性质上是相同的。在离体器官上，Ep的效果比E差，静脉注射后也是如此，然而口服或十二指肠内给药后，Ep的效果更好。这一结果符合以下假设：Ep在首过效应中比E失活程度小，吸收后分解为E和新戊酸。
