Rashkovsky O M, Agoston S, Ket J M
Br J Anaesth. 1985 Nov;57(11):1063-6. doi: 10.1093/bja/57.11.1063.
The interaction between two non-depolarizing neuromuscular blocking agents, pancuronium bromide and vecuronium bromide, has been studied at standardized levels of neuromuscular blockade and alternating the sequence of their administration, in 40 surgical patients. The drug administered first appeared invariably to play a dominant role in influencing both the dose requirements and the duration of action of the subsequent neuromuscular blocker. This resulted in reduced dose requirements and significant prolongation of action of vecuronium administered after pancuronium and increased dose requirements and shortening of neuromuscular blocking action of pancuronium given during vecuronium-induced partial neuromuscular blockade. Possible mechanisms of such interaction are discussed.
在40例外科手术患者中，研究了两种非去极化神经肌肉阻滞剂泮库溴铵和维库溴铵之间的相互作用。研究在标准化神经肌肉阻滞水平下进行，并交替给予这两种药物。首先给予的药物似乎总是在影响后续神经肌肉阻滞剂的剂量需求和作用持续时间方面起主导作用。这导致在泮库溴铵之后给予维库溴铵时，维库溴铵的剂量需求降低且作用时间显著延长；而在维库溴铵诱导的部分神经肌肉阻滞期间给予泮库溴铵时，泮库溴铵的剂量需求增加且神经肌肉阻滞作用时间缩短。文中讨论了这种相互作用的可能机制。
