Pandit S K, Ferres C J, Gibson F M, Mirakhur R K
Anaesthesia. 1986 Feb;41(2):151-4. doi: 10.1111/j.1365-2044.1986.tb13170.x.
Vecuronium 0.1 mg/kg, pancuronium 0.1 mg/kg, vecuronium 0.075 mg/kg + pancuronium 0.025 mg/kg, vecuronium + pancuronium 0.05 mg/kg each and vecuronium 0.025 mg/kg + pancuronium 0.075 mg/kg were compared with respect to time taken to onset of effect, duration of clinical relaxation and intubation conditions in five groups of 20 patients each. The time to onset and intubating conditions were similar in all the groups, indicating that the combinations have no advantage over the individual drugs. The duration of clinical relaxation was 25 minutes with vecuronium, and increased as the proportion of pancuronium in the mixture increased, being 56 minutes with pancuronium 0.1 mg/kg.
将维库溴铵0.1毫克/千克、泮库溴铵0.1毫克/千克、维库溴铵0.075毫克/千克+泮库溴铵0.025毫克/千克、维库溴铵+泮库溴铵各0.05毫克/千克以及维库溴铵0.025毫克/千克+泮库溴铵0.075毫克/千克分别在五组患者（每组20例）中进行比较，观察起效时间、临床松弛持续时间和插管条件。所有组的起效时间和插管条件相似，这表明联合用药并不比单一药物有优势。维库溴铵的临床松弛持续时间为25分钟，随着混合物中泮库溴铵比例的增加而延长，泮库溴铵0.1毫克/千克时为56分钟。
