Hurtado-de-Mendoza David, Loaiza-Bonilla Arturo, Bonilla-Reyes Paula A, Tinoco Gabriel, Alcorta Rodrigo
University of Miami Miller School of Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Florida, USA.
Medicine, Hematology and Oncology, Cancer Treatment Centers of America.
Cureus. 2017 May 18;9(5):e1258. doi: 10.7759/cureus.1258.
Cardio-oncology is a medical discipline that identifies, prevents, and treats the cardiovascular complications related to cancer therapy. Due to the remarkable proliferation of new cancer therapies causing cardiovascular complications, such as hypertension, heart failure, vascular complications, and cardiac arrhythmia, we provide an extensive, comprehensive revision of the most up-to-date scientific information available on the cardiovascular complications associated with the use of newer, novel chemotherapeutic agents, including their reported incidence, suggested pathophysiology, clinical manifestations, potential treatment, and prevention. The authors consider this topic to be relevant for the clinicians since cardiovascular complications associated with the administration of recently approved drugs are relatively underappreciated. The purpose of this article is to provide a state-of-the-art review of cardiovascular complications associated with the use of newer, novel chemotherapeutic agents and targeted therapies, including their reported incidence, suggested pathophysiology, clinical manifestations, potential treatment, and prevention. Ongoing efforts are needed to provide a better understanding of the frequency, mechanisms of disease, prevention, and treatment of cardiovascular complications induced by the newer, novel chemotherapeutic agents. Development of a cardio-oncology discipline is warranted in order to promote task forces aimed at the creation of oncology patient-centered guidelines for the detection, prevention, and treatment of potential cardiovascular side effects associated with newer cancer therapies.
心脏肿瘤学是一门识别、预防和治疗与癌症治疗相关的心血管并发症的医学学科。由于引发心血管并发症（如高血压、心力衰竭、血管并发症和心律失常）的新型癌症治疗方法显著增多，我们对现有关于使用更新型、新型化疗药物相关心血管并发症的最新科学信息进行了广泛、全面的修订，包括其报告的发病率、推测的病理生理学、临床表现、潜在治疗方法和预防措施。作者认为这个主题对临床医生很重要，因为与最近批准药物给药相关的心血管并发症相对未得到充分认识。本文的目的是对与使用更新型、新型化疗药物和靶向治疗相关的心血管并发症进行最新综述，包括其报告的发病率、推测的病理生理学、临床表现、潜在治疗方法和预防措施。需要持续努力以更好地了解更新型、新型化疗药物引起的心血管并发症的发生频率、疾病机制、预防和治疗方法。发展心脏肿瘤学学科是必要的，以便推动特别工作组制定以肿瘤患者为中心的指南，用于检测、预防和治疗与新型癌症治疗相关的潜在心血管副作用。
